CHEBI:2659 - aminophylline

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ChEBI Name aminophylline
ChEBI ID CHEBI:2659
Definition A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C7H8N4O2.C7H8N4O2.C2H8N2
Net Charge 0
Average Mass 420.434
Monoisotopic Mass 420.19820
InChI InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
InChIKey FQPFAHBPWDRTLU-UHFFFAOYSA-N
SMILES C(CN)N.C12=C(N(C(=O)N(C1=O)C)C)N=CN2.C12=C(N(C(N(C1=O)C)=O)C)N=CN2
Roles Classification
Application(s): cardiotonic drug
A drug that has a strengthening effect on the heart or that can increase cardiac output.
bronchodilator agent
An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
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ChEBI Ontology
Outgoing aminophylline (CHEBI:2659) has part ethylenediamine (CHEBI:30347)
aminophylline (CHEBI:2659) has part theophylline (CHEBI:28177)
aminophylline (CHEBI:2659) has role bronchodilator agent (CHEBI:35523)
aminophylline (CHEBI:2659) has role cardiotonic drug (CHEBI:38147)
aminophylline (CHEBI:2659) is a mixture (CHEBI:60004)
IUPAC Name
1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1)
INNs Sources
aminofilina WHO MedNet
aminophylline WHO MedNet
aminophylline WHO MedNet
aminophyllinum WHO MedNet
Synonyms Sources
3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, compd with 1,2-ethanediamine (2:1) ChemIDplus
Aminophylline KEGG DRUG
BY 108 ChemIDplus
ethylenediamine, compd. with theophylline (1:2) ChemIDplus
TAD ChemIDplus
TH/100 ChemIDplus
theophyline ethylenediamine ChemIDplus
theophylline, compd with ethylenediamine (2:1) ChemIDplus
Brand Names Sources
Aminocardol ChemIDplus
Aminodur ChemIDplus
Aminodur dura-tabs ChemIDplus
Aminofillina ChemIDplus
Aminophyllin ChemIDplus
Cardiofilina ChemIDplus
Cardiomin ChemIDplus
Cardophylin ChemIDplus
Cardophyllin ChemIDplus
Carena ChemIDplus
Cariomin ChemIDplus
Diaphilline ChemIDplus
Diaphylline ChemIDplus
Diophllin ChemIDplus
Diophyllin ChemIDplus
Diuxanthine ChemIDplus
Dobo ChemIDplus
Ethophylline ChemIDplus
Etilen-Xantisan ChemIDplus
Eufilina ChemIDplus
Euphyllin ChemIDplus
Euphylline ChemIDplus
Euphyllinum ChemIDplus
Eurphyllin ChemIDplus
Euufilin ChemIDplus
Euufillin ChemIDplus
Genophyllin ChemIDplus
Grifomin ChemIDplus
Inophylline ChemIDplus
Lasodex ChemIDplus
Linampheta ChemIDplus
Lixaminol ChemIDplus
Metaphyllin ChemIDplus
Metaphylline ChemIDplus
Methophylline ChemIDplus
Minaphil ChemIDplus
Miofilin ChemIDplus
Neophyiline ChemIDplus
Neophylline ChemIDplus
Norofilina ChemIDplus
Peterphyllin ChemIDplus
Phylcardin ChemIDplus
Phyllindon ChemIDplus
Phyllocontin ChemIDplus
Rectalad aminophylline ChemIDplus
Somophyllin KEGG DRUG
Stenovasan ChemIDplus
Syntophyllin ChemIDplus
Tefamin ChemIDplus
Theodrox ChemIDplus
Theolamine ChemIDplus
Theolone ChemIDplus
Theomin ChemIDplus
Theophyldine ChemIDplus
Theophyline ethylenediamine ChemIDplus
Theophyllamine ChemIDplus
Theophyllaminium ChemIDplus
Theophyllaminum ChemIDplus
Theophyllin aethylendiamin ChemIDplus
Theophylline ethylenediamine KEGG DRUG
Thephyldine ChemIDplus
Truphylline ChemIDplus
Variaphylline ChemIDplus
Vasofilina ChemIDplus
Manual Xrefs Databases
Aminophylline Wikipedia
D00227 KEGG DRUG
DB01223 DrugBank
View more database links
Registry Numbers Types Sources
317-34-0 CAS Registry Number ChemIDplus
317-34-0 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
10654755 PubMed citation Europe PMC
12615581 PubMed citation Europe PMC
14608279 PubMed citation Europe PMC
17391155 PubMed citation Europe PMC
18568240 PubMed citation Europe PMC
20206069 PubMed citation Europe PMC
21223510 PubMed citation Europe PMC
2636295 PubMed citation Europe PMC
30797981 PubMed citation Europe PMC
31122698 PubMed citation Europe PMC
Last Modified
28 January 2020
General Comment
2020-01-28 A drug combination containing theophylline and ethylenediamine, it has similar pharmacologic actions to theophylline. It is most commonly used to treat bronchial asthma, but has been investigated for several other applications.