CHEBI:138655 - protectin D1

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ChEBI Name protectin D1
ChEBI ID CHEBI:138655
Definition A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Bijay
Supplier Information
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Formula C22H32O4
Net Charge 0
Average Mass 360.488
Monoisotopic Mass 360.23006
InChI InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8+,10-3-,11-6-,17-12-,18-13+/t20-,21+/m0/s1
InChIKey CRDZYJSQHCXHEG-SFVBTVKNSA-N
SMILES OC(CC/C=C\C/C=C\C[C@H](\C=C\C=C\C=C/[C@H](C/C=C\CC)O)O)=O
Metabolite of Species Details
Homo sapiens (NCBI:txid9606) See: PubMed
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): PPARgamma agonist
A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma.
apoptosis inhibitor
Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
human xenobiotic metabolite
Any human metabolite produced by metabolism of a xenobiotic compound in humans.
specialised pro-resolving mediator
A class of cell signaling molecules enzymatically derived from n-3 long chain polyunsaturated fatty acids that have important roles in orchestrating the resolution of tissue inflammation.
Application(s): neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
hepatoprotective agent
Any compound that is able to prevent damage to the liver.
specialised pro-resolving mediator
A class of cell signaling molecules enzymatically derived from n-3 long chain polyunsaturated fatty acids that have important roles in orchestrating the resolution of tissue inflammation.
anti-inflammatory agent
Any compound that has anti-inflammatory effects.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing protectin D1 (CHEBI:138655) has role anti-inflammatory agent (CHEBI:67079)
protectin D1 (CHEBI:138655) has role apoptosis inhibitor (CHEBI:68494)
protectin D1 (CHEBI:138655) has role hepatoprotective agent (CHEBI:62868)
protectin D1 (CHEBI:138655) has role human xenobiotic metabolite (CHEBI:76967)
protectin D1 (CHEBI:138655) has role neuroprotective agent (CHEBI:63726)
protectin D1 (CHEBI:138655) has role PPARγ agonist (CHEBI:71554)
protectin D1 (CHEBI:138655) has role specialised pro-resolving mediator (CHEBI:140399)
protectin D1 (CHEBI:138655) is a dihydroxydocosahexaenoic acid (CHEBI:137348)
protectin D1 (CHEBI:138655) is a secondary allylic alcohol (CHEBI:134396)
Incoming 22-hydroxyprotectin D1 (CHEBI:140243) has functional parent protectin D1 (CHEBI:138655)
IUPAC Name
(4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid
Synonyms Sources
(4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxydocosahexaenoic acid ChEBI
(N)PD1 SUBMITTER
(neuro)protectin D1 ChEBI
10(R),17(S)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid ChEBI
neuroprotectin D1 ChEBI
NPD1 ChEBI
PD1 SUBMITTER
Manual Xrefs Databases
HMDB0003689 HMDB
Protectin_D1 Wikipedia
View more database links
Registry Number Type Source
18351330 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
22690022 PubMed citation Europe PMC
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Last Modified
09 March 2018