CHEBI:55362 - (R)-azelastine

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ChEBI Name (R)-azelastine
ChEBI ID CHEBI:55362
ChEBI ASCII Name (R)-azelastine
Definition The (R)-enantiomer of azelastine.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C22H24ClN3O
Net Charge 0
Average Mass 381.89800
Monoisotopic Mass 381.16079
InChI InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3/t18-/m1/s1
InChIKey MBUVEWMHONZEQD-GOSISDBHSA-N
SMILES CN1CCC[C@H](CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
(via azelastine )
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
(via azelastine )
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
(via azelastine )
anti-allergic agent
A drug used to treat allergic reactions.
(via azelastine )
anti-asthmatic drug
A drug used to treat asthma.
(via azelastine )
bronchodilator agent
An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
(via azelastine )
platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
(via azelastine )
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ChEBI Ontology
Outgoing (R)-azelastine (CHEBI:55362) is a azelastine (CHEBI:2950)
(R)-azelastine (CHEBI:55362) is enantiomer of (S)-azelastine (CHEBI:55363)
Incoming (S)-azelastine (CHEBI:55363) is enantiomer of (R)-azelastine (CHEBI:55362)
IUPAC Name
4-(4-chlorobenzyl)-2-[(4R)-1-methylazepan-4-yl]phthalazin-1(2H)-one
Last Modified
24 August 2012