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ChEBI
> Main
CHEBI:6532 - loperamide
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ChEBI Ontology
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ChEBI Name
loperamide
ChEBI ID
CHEBI:6532
Definition
A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Stars
This entity has been manually annotated by the ChEBI Team.
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Read full article at Wikipedia
Formula
C29H33ClN2O2
Net Charge
0
Average Mass
477.03800
Monoisotopic Mass
476.22306
InChI
InChI=1S/C29H33ClN2O2/c1-
31(2)
27(33)
29(24-
9-
5-
3-
6-
10-
24,25-
11-
7-
4-
8-
12-
25)
19-
22-
32-
20-
17-
28(34,18-
21-
32)
23-
13-
15-
26(30)
16-
14-
23/h3-
16,34H,17-
22H2,1-
2H3
InChIKey
RDOIQAHITMMDAJ-UHFFFAOYSA-N
SMILES
CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
Roles Classification
Biological Role
(s):
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
mu-opioid receptor agonist
A compound that exhibits agonist activity at the
mu
-opioid receptor.
Application
(s):
mu-opioid receptor agonist
A compound that exhibits agonist activity at the
mu
-opioid receptor.
antidiarrhoeal drug
Any drug found useful in the symptomatic treatment of diarrhoea.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
loperamide (
CHEBI:6532
)
has role
μ-opioid receptor agonist (
CHEBI:55322
)
loperamide (
CHEBI:6532
)
has role
anticoronaviral agent (
CHEBI:149553
)
loperamide (
CHEBI:6532
)
has role
antidiarrhoeal drug (
CHEBI:55323
)
loperamide (
CHEBI:6532
)
is a
monocarboxylic acid amide (
CHEBI:29347
)
loperamide (
CHEBI:6532
)
is a
monochlorobenzenes (
CHEBI:83403
)
loperamide (
CHEBI:6532
)
is a
piperidines (
CHEBI:26151
)
loperamide (
CHEBI:6532
)
is a
tertiary alcohol (
CHEBI:26878
)
loperamide (
CHEBI:6532
)
is conjugate base of
loperamide(1+) (
CHEBI:86969
)
Incoming
loperamide(1+) (
CHEBI:86969
)
is conjugate acid of
loperamide (
CHEBI:6532
)
IUPAC Name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-
N
,
N
-dimethyl-2,2-diphenylbutanamide
INNs
Sources
loperamida
ChemIDplus
loperamide
ChemIDplus
loperamidum
ChemIDplus
Synonyms
Sources
lopéramide
WHO MedNet
Loperamide
KEGG COMPOUND
Manual Xrefs
Databases
1599
DrugCentral
C07080
KEGG COMPOUND
D08144
KEGG DRUG
DB00836
DrugBank
FR2100711
Patent
HMDB0004999
HMDB
Loperamide
Wikipedia
LSM-3365
LINCS
US3714159
Patent
View more database links
Registry Numbers
Types
Sources
1558273
Reaxys Registry Number
Reaxys
53179-11-6
CAS Registry Number
ChemIDplus
Citations
Types
Sources
15900907
PubMed citation
Europe PMC
19034106
PubMed citation
Europe PMC
24398461
PubMed citation
Europe PMC
Last Modified
23 April 2020