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> Main
CHEBI:17276 - phloretin
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ChEBI Name
phloretin
ChEBI ID
CHEBI:17276
Definition
A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Stars
This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs
CHEBI:26014, CHEBI:42649, CHEBI:8111, CHEBI:14787
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Formula
C15H14O5
Net Charge
0
Average Mass
274.26866
Monoisotopic Mass
274.08412
InChI
InChI=1S/C15H14O5/c16-
10-
4-
1-
9(2-
5-
10)
3-
6-
12(18)
15-
13(19)
7-
11(17)
8-
14(15)
20/h1-
2,4-
5,7-
8,16-
17,19-
20H,3,6H2
InChIKey
VGEREEWJJVICBM-UHFFFAOYSA-N
SMILES
Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
Roles Classification
Biological Role
(s):
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
Application
(s):
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
phloretin (
CHEBI:17276
)
has functional parent
dihydrochalcone (
CHEBI:71231
)
phloretin (
CHEBI:17276
)
has role
antineoplastic agent (
CHEBI:35610
)
phloretin (
CHEBI:17276
)
has role
plant metabolite (
CHEBI:76924
)
phloretin (
CHEBI:17276
)
is a
dihydrochalcones (
CHEBI:71230
)
Incoming
3-hydroxyphloretin 2'-
O
-xylosylglucoside (
CHEBI:88354
)
has functional parent
phloretin (
CHEBI:17276
)
asebogenin (
CHEBI:2871
)
has functional parent
phloretin (
CHEBI:17276
)
glycyphyllin (
CHEBI:27400
)
has functional parent
phloretin (
CHEBI:17276
)
phlorizin (
CHEBI:8113
)
has functional parent
phloretin (
CHEBI:17276
)
trilobatin (
CHEBI:145829
)
has functional parent
phloretin (
CHEBI:17276
)
IUPAC Name
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Synonyms
Sources
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
ChEBI
Phloretin
KEGG COMPOUND
phloretin
UniProt
Manual Xrefs
Databases
C00007936
KNApSAcK
C00774
KEGG COMPOUND
CN102701938
Patent
CN103230408
Patent
DB07810
DrugBank
G50
PDBeChem
HMDB0003306
HMDB
LMPK12120525
LIPID MAPS
LSM-6221
LINCS
Phloretin
Wikipedia
PHLORETIN
MetaCyc
View more database links
Registry Numbers
Types
Sources
1887240
Reaxys Registry Number
Reaxys
60-82-2
CAS Registry Number
KEGG COMPOUND
60-82-2
CAS Registry Number
ChemIDplus
Citations
Types
Sources
18767070
PubMed citation
Europe PMC
23907072
PubMed citation
Europe PMC
24487097
PubMed citation
Europe PMC
7126563
PubMed citation
Europe PMC
Last Modified
21 January 2020