CHEBI:71023 - alcaftadine

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ChEBI Name alcaftadine
ChEBI ID CHEBI:71023
Definition An imidazobenzazepine that is 6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine substituted at position 3 by a formyl group and at position 11 by a 1-methylpiperidin-4-ylidene group. An antihistamine used for treatment of allergic conjunctivitis.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C19H21N3O
Net Charge 0
Average Mass 307.38950
Monoisotopic Mass 307.16846
InChI InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3
InChIKey MWTBKTRZPHJQLH-UHFFFAOYSA-N
SMILES [H]C(=O)c1cnc2C(=C3CCN(C)CC3)c3ccccc3CCn12
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
anti-allergic agent
A drug used to treat allergic reactions.
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ChEBI Ontology
Outgoing alcaftadine (CHEBI:71023) has role anti-allergic agent (CHEBI:50857)
alcaftadine (CHEBI:71023) has role H1-receptor antagonist (CHEBI:37955)
alcaftadine (CHEBI:71023) is a aldehyde (CHEBI:17478)
alcaftadine (CHEBI:71023) is a imidazobenzazepine (CHEBI:71024)
alcaftadine (CHEBI:71023) is a piperidines (CHEBI:26151)
alcaftadine (CHEBI:71023) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde
INNs Sources
alcaftadina WHO MedNet
alcaftadine KEGG DRUG
alcaftadine WHO MedNet
alcaftadinum WHO MedNet
Brand Name Source
Lastacaft KEGG DRUG
Manual Xrefs Databases
4165 DrugCentral
Alcaftadine Wikipedia
CN101460176 Patent
D06552 KEGG DRUG
DB06766 DrugBank
HMDB0015670 HMDB
KR20080110881 Patent
MX2008012657 Patent
US2008051385 Patent
US2008139531 Patent
US2012094978 Patent
US5468743 Patent
WO2007117971 Patent
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Registry Numbers Types Sources
13759211 Reaxys Registry Number Reaxys
147084-10-4 CAS Registry Number KEGG DRUG
147084-10-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
21250860 PubMed citation Europe PMC
21314437 PubMed citation Europe PMC
21339800 PubMed citation Europe PMC
21340041 PubMed citation Europe PMC
21383667 PubMed citation Europe PMC
21752782 PubMed citation Europe PMC
22348913 PubMed citation Europe PMC
22811343 PubMed citation Europe PMC
Last Modified
22 February 2017