CHEBI:69621 - trichothecin

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ChEBI Name trichothecin
ChEBI ID CHEBI:69621
Definition A trichothecene mycototoxin isolated from the endophytic fungus Trichothecium sp. and it exhibits anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:9692
Supplier Information
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Formula C19H24O5
Net Charge 0
Average Mass 332.396
Monoisotopic Mass 332.16237
InChI InChI=1S/C19H24O5/c1-5-6-16(21)24-14-8-15-19(10-22-19)18(14,4)17(3)9-12(20)11(2)7-13(17)23-15/h5-7,13-15H,8-10H2,1-4H3/b6-5-/t13-,14-,15-,17+,18-,19+/m1/s1
InChIKey LJWZOKOFCBPNAG-HULHSAFCSA-N
SMILES [H][C@@]12C[C@@H](OC(=O)\C=C/C)[C@@](C)([C@]11CO1)[C@@]1(C)CC(=O)C(C)=C[C@@]1([H])O2
Metabolite of Species Details
Trichothecium sp. MSX_51320 (NCBI:txid1094547) Mycosynthetix fungal strain was isolated by Dr.Barry Katz from leaf litter See: PubMed
Engleromyces goetzii (NCBI:txid251718) See: PubMed
Holarrhena floribunda (NCBI:txid2708850) Found in stem (BTO:0001300). See: PubMed
Trichothecium roseum (NCBI:txid47278) See: PubMed
Trichothecium roseum (NCBI:txid47278) of strain LZ93 See: PubMed
Roles Classification
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
mycotoxin
Poisonous substance produced by fungi.
(via trichothecene )
protein synthesis inhibitor
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
STAT3 inhibitor
An inhibitor of signal transducer and activator of transcription 3 (STAT3)
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing trichothecin (CHEBI:69621) has role antifungal agent (CHEBI:35718)
trichothecin (CHEBI:69621) has role antineoplastic agent (CHEBI:35610)
trichothecin (CHEBI:69621) has role apoptosis inducer (CHEBI:68495)
trichothecin (CHEBI:69621) has role mycotoxin (CHEBI:25442)
trichothecin (CHEBI:69621) has role protein synthesis inhibitor (CHEBI:48001)
trichothecin (CHEBI:69621) has role STAT3 inhibitor (CHEBI:87183)
trichothecin (CHEBI:69621) is a trichothecene (CHEBI:55517)
IUPAC Name
8-oxo-12,13-epoxytrichothec-9-en-4β-yl (2Z)-but-2-enoate
Synonyms Sources
(4β)-12,13-epoxy-4-[[(2Z)-1-oxo-2-butenyl]oxy]trichothec-9-en-8-one ChEBI
trichothecin KEGG COMPOUND
Manual Xrefs Databases
10216230 ChemSpider
C00003196 KNApSAcK
C09742 KEGG COMPOUND
View more database links
Registry Numbers Types Sources
6379-69-7 CAS Registry Number KEGG COMPOUND
6379-69-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10650079 PubMed citation Europe PMC
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IND607358060 Agricola citation Europe PMC
Last Modified
15 October 2021