mannostatin A (CHEBI:191195)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	mannostatin A

ChEBI ID	CHEBI:191195

Definition	An amino cyclitol that is cyclopentane substituted by hydroxy groups at positions 1, 2 and 3, by an amino group at positon 4, and by a methylsulfanediyl group at position 5 (the 1R,2R,3R,4S,5R-stereoisomer). It is isolated from the soil bacterium Streptoverticillium verticillium.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:44106

Supplier Information

Download	Molfile XML SDF

more structures >>

Formula

C6H13NO3S

Net Charge

Average Mass

179.230

Monoisotopic Mass

179.06161

InChI

InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1

InChIKey

BLOFGONIVNXZME-YDMGZANHSA-N

SMILES

CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O

Metabolite of Species	Details
Streptoverticillium verticillium subsp. quintum (NCBI:txid1433418)	of strain ME3-AG3 See: PubMed

Roles Classification
Biological Role(s):	EC 3.2.1.24 (alpha-mannosidase) inhibitor An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-mannosidase (EC 3.2.1.24). bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor An enzyme inhibitor that interferes with the action of mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114), a key enzyme target in the development of anti-cancer therapies.

ChEBI Ontology
Outgoing	mannostatin A (CHEBI:191195) has role bacterial metabolite (CHEBI:76969) mannostatin A (CHEBI:191195) has role EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-α-mannosidase) inhibitor (CHEBI:65239) mannostatin A (CHEBI:191195) has role EC 3.2.1.24 (α-mannosidase) inhibitor (CHEBI:191196) mannostatin A (CHEBI:191195) is a amino cyclitol (CHEBI:61689) mannostatin A (CHEBI:191195) is a methyl sulfide (CHEBI:86315) mannostatin A (CHEBI:191195) is a triol (CHEBI:27136)

IUPAC Name

(1R,2R,3R,4S,5R)-4-amino-5-(methylsulfanyl)cyclopentane-1,2,3-triol

Synonyms	Sources
(+)-mannostatin A	KNApSAcK
(1R,2R,3R,4S,5R)-4-amino-5-(methylthio)-1,2,3-cyclopentanetriol	ChEBI
(1R,2R,3R,4S,5R)-4-amino-5-(methylthio)cyclopentane-1,2,3-triol	PDBeChem
mannostatin	ChemIDplus

Last Modified

21 April 2022