CHEBI:167653 - AZD3463

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name AZD3463
ChEBI ID CHEBI:167653
Definition A member of the class of indoles that is 1H-indole substituted by a 2-[4-(4-aminopiperidin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl group at position 3. It is an orally bioavailable dual inhibitor of ALK and IGF1R with Ki value of 0.75 nM for ALK.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter R. Stephan
Supplier Information
Download Molfile XML SDF
more structures >>
Formula C24H25ClN6O
Net Charge 0
Average Mass 448.960
Monoisotopic Mass 448.17784
InChI InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)
InChIKey GCYIGMXOIWJGBU-UHFFFAOYSA-N
SMILES COC1=C(NC2=NC=C(Cl)C(=N2)C2=CNC3=CC=CC=C23)C=CC(=C1)N1CCC(N)CC1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
autophagy inducer
Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing AZD3463 (CHEBI:167653) has role antineoplastic agent (CHEBI:35610)
AZD3463 (CHEBI:167653) has role apoptosis inducer (CHEBI:68495)
AZD3463 (CHEBI:167653) has role autophagy inducer (CHEBI:138880)
AZD3463 (CHEBI:167653) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
AZD3463 (CHEBI:167653) is a aminopiperidine (CHEBI:48588)
AZD3463 (CHEBI:167653) is a aminopyrimidine (CHEBI:38338)
AZD3463 (CHEBI:167653) is a indoles (CHEBI:24828)
AZD3463 (CHEBI:167653) is a monomethoxybenzene (CHEBI:25235)
AZD3463 (CHEBI:167653) is a organochlorine compound (CHEBI:36683)
AZD3463 (CHEBI:167653) is a secondary amino compound (CHEBI:50995)
AZD3463 (CHEBI:167653) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
Synonyms Sources
N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine ChEBI
AZD 3463 ChEBI
AZD-3463 ChEBI
Manual Xref Database
29315067 ChemSpider
View more database links
Registry Number Type Source
1356962-20-3 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
26571493 PubMed citation Europe PMC
26786851 PubMed citation SUBMITTER
30647405 PubMed citation Europe PMC
31346159 PubMed citation Europe PMC
32355780 PubMed citation SUBMITTER
32698744 PubMed citation Europe PMC
33109342 PubMed citation Europe PMC
33141044 PubMed citation Europe PMC
Last Modified
15 March 2021