lificiguat (CHEBI:142430)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	lificiguat

ChEBI ID	CHEBI:142430

Definition	A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Bijay

Supplier Information

Download	Molfile XML SDF

Formula

C19H16N2O2

Net Charge

Average Mass

304.343

Monoisotopic Mass

304.12118

InChI

InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2

InChIKey

OQQVFCKUDYMWGV-UHFFFAOYSA-N

SMILES

C(N1N=C(C2=C1C=CC=C2)C=3OC(=CC3)CO)C=4C=CC=CC4

Roles Classification
Biological Role(s):	soluble guanylate cyclase activator Any compound that binds to and activates soluble guanylate cyclase (EC 4.6.1.2). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. vasodilator agent A drug used to cause dilation of the blood vessels.

ChEBI Ontology
Outgoing	lificiguat (CHEBI:142430) has role antineoplastic agent (CHEBI:35610) lificiguat (CHEBI:142430) has role apoptosis inducer (CHEBI:68495) lificiguat (CHEBI:142430) has role platelet aggregation inhibitor (CHEBI:50427) lificiguat (CHEBI:142430) has role soluble guanylate cyclase activator (CHEBI:76022) lificiguat (CHEBI:142430) has role vasodilator agent (CHEBI:35620) lificiguat (CHEBI:142430) is a aromatic primary alcohol (CHEBI:33857) lificiguat (CHEBI:142430) is a furans (CHEBI:24129) lificiguat (CHEBI:142430) is a indazoles (CHEBI:38769)

IUPAC Name

[5-(1-benzyl-1H-indazol-3-yl)-2-furyl]methanol

Synonyms	Sources
1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole	ChEBI
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	ChEBI
YC-1	SUBMITTER

Last Modified

25 October 2018