CHEBI:4703 - dorzolamide hydrochloride

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ChEBI Name dorzolamide hydrochloride
ChEBI ID CHEBI:4703
Definition The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C10H17ClN2O4S3
Net Charge 0
Average Mass 360.90100
Monoisotopic Mass 360.00390
InChI InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
InChIKey OSRUSFPMRGDLAG-QMGYSKNISA-N
SMILES [Cl-].CC[NH2+][C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
Roles Classification
Biological Role(s): EC 4.2.1.1 (carbonic anhydrase) inhibitor
An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
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ChEBI Ontology
Outgoing dorzolamide hydrochloride (CHEBI:4703) has part dorzolamide (CHEBI:4702)
dorzolamide hydrochloride (CHEBI:4703) has role antiglaucoma drug (CHEBI:39456)
dorzolamide hydrochloride (CHEBI:4703) has role antihypertensive agent (CHEBI:35674)
dorzolamide hydrochloride (CHEBI:4703) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018)
dorzolamide hydrochloride (CHEBI:4703) is a hydrochloride (CHEBI:36807)
dorzolamide hydrochloride (CHEBI:4703) is a organoammonium salt (CHEBI:46850)
IUPAC Name
(SS,6S)-N-ethyl-6-methyl-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-aminium 7,7-dioxide chloride
Synonyms Sources
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4HH-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride ChemIDplus
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride IUPAC
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride ChEBI
dorzolamide HCl ChemIDplus
Manual Xrefs Databases
D00653 KEGG DRUG
DB00869 DrugBank
View more database links
Registry Numbers Types Sources
130693-82-2 CAS Registry Number ChemIDplus
130693-82-2 CAS Registry Number KEGG DRUG
5896026 Beilstein Registry Number Beilstein
Last Modified
21 July 2010