loxapine (CHEBI:50841)

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ChEBI Name	loxapine

ChEBI ID	CHEBI:50841

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:50839, CHEBI:6548

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Formula

C18H18ClN3O

Net Charge

Average Mass

327.80784

Monoisotopic Mass

327.11384

InChI

InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

InChIKey

XJGVXQDUIWGIRW-UHFFFAOYSA-N

SMILES

CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12

Roles Classification
Biological Role(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.

Application(s):	antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.

ChEBI Ontology
Outgoing	loxapine (CHEBI:50841) has role antipsychotic agent (CHEBI:35476) loxapine (CHEBI:50841) has role dopaminergic antagonist (CHEBI:48561) loxapine (CHEBI:50841) is a dibenzooxazepine (CHEBI:53802)

Incoming	loxapine succinate (CHEBI:6549) has part loxapine (CHEBI:50841)

IUPAC Name

2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine

Synonyms	Sources
2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine	NIST Chemistry WebBook
Loxapine	KEGG COMPOUND
oxilapine	ChemIDplus

Brand Name	Source
Cloxazepine	DrugBank

Last Modified

22 February 2017