CHEBI:149635 - β-casomorphin-7 (human)

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ChEBI Name β-casomorphin-7 (human)
ChEBI ID CHEBI:149635
ChEBI ASCII Name beta-casomorphin-7 (human)
Definition A seven amino acid oligopeptide fragment of the human milk protein, β-casein. It is an inhibitor of pancreatic elastase, 5-HT2-serotonin receptors, μ-opioid receptors and δ-opioid receptors.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C44H61N7O11
Net Charge 0
Average Mass 864.010
Monoisotopic Mass 863.44291
InChI InChI=1S/C44H61N7O11/c1-5-26(4)37(44(61)62)49-40(57)34-14-10-22-51(34)43(60)31(19-20-35(53)54)46-41(58)36(25(2)3)48-38(55)32(24-27-11-7-6-8-12-27)47-39(56)33-13-9-21-50(33)42(59)30(45)23-28-15-17-29(52)18-16-28/h6-8,11-12,15-18,25-26,30-34,36-37,52H,5,9-10,13-14,19-24,45H2,1-4H3,(H,46,58)(H,47,56)(H,48,55)(H,49,57)(H,53,54)(H,61,62)/t26-,30-,31-,32-,33-,34-,36-,37-/m0/s1
InChIKey ADBHAJDGVKLXHK-LMXUZNBISA-N
SMILES C(CC[C@@H](C(N1[C@@H](CCC1)C(=O)N[C@@H]([C@H](CC)C)C(O)=O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC(=O)[C@H]3N(CCC3)C([C@H](CC4=CC=C(C=C4)O)N)=O)=O)=O)(=O)O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): mu-opioid receptor antagonist
Any compound that exhibits antagonist activity at the mu-opioid receptor
delta-opioid receptor antagonist
Any compound that exhibits antagonist activity at the delta-opioid receptor.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
EC 3.4.21.36 (pancreatic elastase) inhibitor
An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the activity of pancreatic elastase (EC 3.4.21.36).
Application(s): mu-opioid receptor antagonist
Any compound that exhibits antagonist activity at the mu-opioid receptor
delta-opioid receptor antagonist
Any compound that exhibits antagonist activity at the delta-opioid receptor.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing β-casomorphin-7 (human) (CHEBI:149635) has role δ-opioid receptor antagonist (CHEBI:59283)
β-casomorphin-7 (human) (CHEBI:149635) has role μ-opioid receptor antagonist (CHEBI:50137)
β-casomorphin-7 (human) (CHEBI:149635) has role EC 3.4.21.36 (pancreatic elastase) inhibitor (CHEBI:149639)
β-casomorphin-7 (human) (CHEBI:149635) has role human metabolite (CHEBI:77746)
β-casomorphin-7 (human) (CHEBI:149635) has role serotonergic antagonist (CHEBI:48279)
β-casomorphin-7 (human) (CHEBI:149635) is a oligopeptide (CHEBI:25676)
β-casomorphin-7 (human) (CHEBI:149635) is conjugate acid of β-casomorphin-7 (human)(1−) (CHEBI:147390)
Incoming β-casomorphin-7 (human)(1−) (CHEBI:147390) is conjugate base of β-casomorphin-7 (human) (CHEBI:149635)
IUPAC Name
L-tyrosyl-L-prolyl-L-phenylalanyl-L-valyl-L-α-glutamyl-L-prolyl-L-isoleucine
Synonyms Sources
H-Tyr-Pro-Phe-Val-Glu-Pro-Ile-OH ChEBI
human β-casomorphin (1-7) ChEBI
human β-casomorphin-7 ChEBI
L-Tyr-L-Pro-L-Phe-L-Val-L-Glu-L-Pro-L-Ile ChEBI
NH2-Tyr-Pro-Phe-Val-Glu-Pro-Ile-COOH ChEBI
Tyr-Pro-Phe-Val-Glu-Pro-Ile ChEBI
Y-P-F-V-E-P-I ChEBI
YPFVEPI ChEBI
Manual Xref Database
US2010286029 Patent
View more database links
Registry Number Type Source
102029-74-3 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
11358514 PubMed citation Europe PMC
16472079 PubMed citation Europe PMC
16758631 PubMed citation Europe PMC
3005882 PubMed citation Europe PMC
9187653 PubMed citation Europe PMC
9606940 PubMed citation Europe PMC
Last Modified
05 May 2020