diclofenamide (CHEBI:101085)

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ChEBI Name	diclofenamide

ChEBI ID	CHEBI:101085

Definition	A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:47477, CHEBI:4505

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Formula

C6H6Cl2N2O4S2

Net Charge

Average Mass

305.15900

Monoisotopic Mass

303.91460

InChI

InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)

InChIKey

GJQPMPFPNINLKP-UHFFFAOYSA-N

SMILES

NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O

Roles Classification
Biological Role(s):	EC 4.2.1.1 (carbonic anhydrase) inhibitor An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.

Application(s):	antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases.

ChEBI Ontology
Outgoing	diclofenamide (CHEBI:101085) has role antiglaucoma drug (CHEBI:39456) diclofenamide (CHEBI:101085) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018) diclofenamide (CHEBI:101085) has role ophthalmology drug (CHEBI:66981) diclofenamide (CHEBI:101085) is a dichlorobenzene (CHEBI:23697) diclofenamide (CHEBI:101085) is a sulfonamide (CHEBI:35358)

IUPAC Name

4,5-dichlorobenzene-1,3-disulfonamide

Synonyms	Sources
1,3-disulfamoyl-4,5-dichlorobenzene	ChemIDplus
1,3-disulfamyl-4,5-dichlorobenzene	ChemIDplus
3,4-dichloro-5-sulfamylbenzenesulfonamide	ChemIDplus
4,5-dichloro-1,3-benzenedisulfonamide	NIST Chemistry WebBook
4,5-dichloro-1,3-disulfamoylbenzene	ChemIDplus
4,5-dichloro-benzene-1,3-disulfonic acid diamide	ChEMBL
4,5-dichloro-m-benzenedisulfonamide	ChemIDplus
4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE	PDBeChem
Dichlorophenamide	ChEMBL
dichlorophenamide	ChEMBL
Dichlorphenamide	KEGG COMPOUND
DICHLORPHENAMIDE	ChEMBL
dichlorphenamide	ChEMBL
Diclofenamide	KEGG COMPOUND
DICLOFENAMIDE	ChEMBL

Last Modified

22 February 2017