SKF-96365 hydrochloride (CHEBI:145121)

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ChEBI Name	SKF-96365 hydrochloride

ChEBI ID	CHEBI:145121

Definition	The hydrochloride salt of SKF-96365. It is a TRP channel blocker.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	TheOtherDave

Supplier Information

Download	Molfile XML SDF

Formula

C22H26N2O3.ClH

Net Charge

Average Mass

402.920

Monoisotopic Mass

402.17102

InChI

InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H

InChIKey

FWLPKVQUECFKSW-UHFFFAOYSA-N

SMILES

C=1(C=CC(=CC1)OC)C(CN2C=NC=C2)OCCCC3=CC=C(C=C3)OC.[H]Cl

Roles Classification
Biological Role(s):	TRP channel blocker An agent that inhibits the passage of cations through the transient receptor potential (TRP) channels. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. autophagy inducer Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). GABA antagonist A compound that inhibits the action of gamma-aminobutyric acid. calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.

Application(s):	GABA antagonist A compound that inhibits the action of gamma-aminobutyric acid. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

ChEBI Ontology
Outgoing	SKF-96365 hydrochloride (CHEBI:145121) has part SKF-96365 free base(1+) (CHEBI:145128) SKF-96365 hydrochloride (CHEBI:145121) has role antineoplastic agent (CHEBI:35610) SKF-96365 hydrochloride (CHEBI:145121) has role apoptosis inducer (CHEBI:68495) SKF-96365 hydrochloride (CHEBI:145121) has role autophagy inducer (CHEBI:138880) SKF-96365 hydrochloride (CHEBI:145121) has role calcium channel blocker (CHEBI:38215) SKF-96365 hydrochloride (CHEBI:145121) has role GABA antagonist (CHEBI:65259) SKF-96365 hydrochloride (CHEBI:145121) has role platelet aggregation inhibitor (CHEBI:50427) SKF-96365 hydrochloride (CHEBI:145121) has role TRP channel blocker (CHEBI:139361) SKF-96365 hydrochloride (CHEBI:145121) is a hydrochloride (CHEBI:36807)

IUPAC Name

1-{2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride

Synonyms	Sources
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride	ChEBI
SK&F 96365	ChemIDplus
SK&F-96365	ChEBI
SKF-96365 HCl	ChEBI
SKF-963656	ChEBI
SKF963656	SUBMITTER

Last Modified

21 October 2019