CHEBI:9364 - suramin sodium

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name suramin sodium
ChEBI ID CHEBI:9364
Definition An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formulae C51H34N6O23S6.6Na
C51H34N6O23S6.Na.Na.Na.Na.Na.Na
Net Charge 0
Average Mass 1429.150
Monoisotopic Mass 1427.93857
InChI InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
InChIKey VAPNKLKDKUDFHK-UHFFFAOYSA-H
SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=CC(=CC=C2C)C(=O)NC2=CC=C(C3=CC(=CC(=C23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C1)C(=O)NC1=CC=C(C2=CC(=CC(=C12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
Roles Classification
Biological Role(s): trypanocidal drug
A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
apoptosis inhibitor
Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.11.13 (protein kinase C) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
GABA antagonist
A compound that inhibits the action of gamma-aminobutyric acid.
GABA-gated chloride channel antagonist

purinergic receptor P2 antagonist
An antagonist at purinergic P2 receptors
ryanodine receptor agonist
A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
Application(s): antinematodal drug
A substance used in the treatment or control of nematode infestations.
trypanocidal drug
A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
GABA antagonist
A compound that inhibits the action of gamma-aminobutyric acid.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing suramin sodium (CHEBI:9364) has part suramin(6−) (CHEBI:180911)
suramin sodium (CHEBI:9364) has role angiogenesis inhibitor (CHEBI:48422)
suramin sodium (CHEBI:9364) has role antinematodal drug (CHEBI:35444)
suramin sodium (CHEBI:9364) has role antineoplastic agent (CHEBI:35610)
suramin sodium (CHEBI:9364) has role apoptosis inhibitor (CHEBI:68494)
suramin sodium (CHEBI:9364) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700)
suramin sodium (CHEBI:9364) has role GABA antagonist (CHEBI:65259)
suramin sodium (CHEBI:9364) has role GABA-gated chloride channel antagonist (CHEBI:38999)
suramin sodium (CHEBI:9364) has role purinergic receptor P2 antagonist (CHEBI:91079)
suramin sodium (CHEBI:9364) has role ryanodine receptor agonist (CHEBI:67114)
suramin sodium (CHEBI:9364) has role trypanocidal drug (CHEBI:36335)
suramin sodium (CHEBI:9364) is a organic sodium salt (CHEBI:38700)
IUPAC Name
hexasodium 8,8'-{carbonylbis[iminobenzene-3,1-diylcarbonylimino(4-methylbenzene-3,1-diyl)carbonylimino]}dinaphthalene-1,3,5-trisulfonate
INNs Sources
suramin sodium WHO MedNet
suramina de sodio WHO MedNet
suramine sodique WHO MedNet
suraminum natricum WHO MedNet
Synonyms Sources
8,8'-[ureylenebis[m-phenylene carbonylimino(4-methyl-m-phenylene)carbonylimino]]di(1,3,5-naphthalenetrisulfonic acid) hexasodium salt ChEBI
BAY 205 ChemIDplus
CI 1003 ChemIDplus
CI-1003 ChemIDplus
NF 060 ChemIDplus
SK 24728 ChemIDplus
suramin hexasodium ChemIDplus
Brand Names Sources
Antrypol ChemIDplus
Bayer 205 KEGG DRUG
Fourneau 309 ChemIDplus
Germanin ChemIDplus
Moranyl ChemIDplus
Naganin ChemIDplus
Naganine ChemIDplus
Naganinum ChemIDplus
Naganol ChemIDplus
Naphuride sodium ChemIDplus
Manual Xrefs Databases
5167 ChemSpider
D00808 KEGG DRUG
DBSALT000540 DrugBank
US4737521 Patent
View more database links
Registry Number Type Source
129-46-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10763460 PubMed citation Europe PMC
13065125 PubMed citation Europe PMC
13291367 PubMed citation Europe PMC
13586201 PubMed citation Europe PMC
13661600 PubMed citation Europe PMC
16746601 PubMed citation Europe PMC
16746889 PubMed citation Europe PMC
16747021 PubMed citation Europe PMC
16748363 PubMed citation Europe PMC
16748617 PubMed citation Europe PMC
21563369 PubMed citation Europe PMC
23562880 PubMed citation Europe PMC
27180636 PubMed citation Europe PMC
30530630 PubMed citation Europe PMC
3454811 PubMed citation Europe PMC
454406 PubMed citation Europe PMC
4881068 PubMed citation Europe PMC
7790120 PubMed citation Europe PMC
8597272 PubMed citation Europe PMC
Last Modified
15 October 2021