GDC-0623 (CHEBI:167659)

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ChEBI Name	GDC-0623

ChEBI ID	CHEBI:167659

Definition	A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	R. Stephan

Supplier Information

Download	Molfile XML SDF

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Formula

C16H14FIN4O3

Net Charge

Average Mass

456.216

Monoisotopic Mass

456.00946

InChI

InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)

InChIKey

RFWVETIZUQEJEF-UHFFFAOYSA-N

SMILES

OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)N2C=NC=C2C=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of mitogen-activated protein kinase kinase (EC 2.7.12.2). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	GDC-0623 (CHEBI:167659) has role antineoplastic agent (CHEBI:35610) GDC-0623 (CHEBI:167659) has role apoptosis inducer (CHEBI:68495) GDC-0623 (CHEBI:167659) has role EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor (CHEBI:88286) GDC-0623 (CHEBI:167659) is a hydroxamic acid ester (CHEBI:75606) GDC-0623 (CHEBI:167659) is a imidazopyridine (CHEBI:46908) GDC-0623 (CHEBI:167659) is a monofluorobenzenes (CHEBI:83575) GDC-0623 (CHEBI:167659) is a organoiodine compound (CHEBI:37142) GDC-0623 (CHEBI:167659) is a primary alcohol (CHEBI:15734) GDC-0623 (CHEBI:167659) is a secondary amino compound (CHEBI:50995) GDC-0623 (CHEBI:167659) is a substituted aniline (CHEBI:48975)

IUPAC Name

5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide

Synonyms	Sources
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	ChEBI
G 868	ChEBI
G-868	ChEBI
G868	ChEBI
GDC 0623	ChemIDplus
GDC0623	ChEBI
RG 7421	ChemIDplus
RG-7421	ChEBI

Registry Number	Type	Source
1168091-68-6	CAS Registry Number	ChemIDplus

Last Modified

17 March 2021