2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427)

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ChEBI Name	2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene

ChEBI ID	CHEBI:194427

ChEBI ASCII Name	2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene

Definition	A member of the class of chromenes that is 4H-chromene substituted by amino, cyano, 2-methoxyphenyl, and dimethylamino groups at positions 2, 3, 4 and 7, respectively. It exhibits anti-angiogenic activity.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C19H19N3O2

Net Charge

Average Mass

321.380

Monoisotopic Mass

321.14773

InChI

InChI=1S/C19H19N3O2/c1-22(2)12-8-9-14-17(10-12)24-19(21)15(11-20)18(14)13-6-4-5-7-16(13)23-3/h4-10,18H,21H2,1-3H3

InChIKey

FUBZFCWMCGQOOE-UHFFFAOYSA-N

SMILES

COC1=CC=CC=C1C1C2=CC=C(C=C2OC(N)=C1C#N)N(C)C

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology
Outgoing	2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) has role angiogenesis inhibitor (CHEBI:48422) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) has role antineoplastic agent (CHEBI:35610) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) has role apoptosis inducer (CHEBI:68495) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) is a aminochromene (CHEBI:38676) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) is a monomethoxybenzene (CHEBI:25235) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) is a nitrile (CHEBI:18379) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) is a primary amino compound (CHEBI:50994) 2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene (CHEBI:194427) is a tertiary amino compound (CHEBI:50996)

IUPAC Name

2-amino-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene-3-carbonitrile

Synonyms	Sources
2-amino-4-(2-methoxyphenyl)-3-cyano-7-(dimethylamino)-4H-chromene	ChEBI
2-amino-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-1-benzopyran-3-carbonitrile	IUPAC

Last Modified

21 February 2023

General Comment
2023-02-21	Relevant article: https://doi.org/10.1007/s00044-010-9418-y