CHEBI:85662 - lixisenatide

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ChEBI Name lixisenatide ChEBI ID CHEBI:85662 Definition A forty-four membered polypeptide consisting of L-His, Gly, L-Glu, Gly, L-Thr, L-Phe, L-Thr, L-Ser, L-Asp, L-Leu, L-Ser, L-Lys, L-Gln, L-Met, L-Glu, L-Glu, L-Glu, L-Ala, L-Val, L-Arg, L-Leu, L-Phe, L-Ile, L-Glu, L-Trp, L-Leu, L-Lys, L-Asn, Gly, Gly, LPro, L-Ser, L-Ser, Gly, L-Ala, L-Pro, L-Pro, L-Ser, L-Lys, L-Lys, L-Lys, L-Lys, L-Lys, and L-Lys-NH2 residues joined in sequence. Used as an adjunct to diet and exercise for the treatment of adults with type II diabetes. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C215H347N61O65S Net Charge 0 Average Mass 4858.49000 Monoisotopic Mass 4855.54432 InChI InChI=1S/C215H347N61O65S/c1-16-115(10)173(210(337)256-141(68-74-170(299)300)194(321)261-148(94-122-98-232-126-50-24-23-49-124(122)126)199(326)258-143(89-111(2)3)196(323)247-134(58-32-40-83-223)189(316)262-149(96-160(226)285)180(307)235-100-161(286)233-104-165(290)274-85-42-60-156(274)207(334)267-154(108-280)206(333)265-151(105-277)181(308)237-101-162(287)239-117(12)213(340)276-87-44-62-158(276)214(341)275-86-43-61-157(275)208(335)268-153(107-279)204(331)249-132(56-30-38-81-221)187(314)246-131(55-29-37-80-220)186(313)245-130(54-28-36-79-219)185(312)244-129(53-27-35-78-218)184(311)243-128(52-26-34-77-217)183(310)242-127(176(227)303)51-25-33-76-216)272-201(328)146(92-120-45-19-17-20-46-120)260-197(324)144(90-112(4)5)257-190(317)135(59-41-84-231-215(228)229)255-209(336)172(114(8)9)271-177(304)116(11)240-182(309)138(65-71-167(293)294)251-192(319)139(66-72-168(295)296)252-193(320)140(67-73-169(297)298)253-195(322)142(75-88-342-15)254-191(318)137(63-69-159(225)284)250-188(315)133(57-31-39-82-222)248-203(330)152(106-278)266-198(325)145(91-113(6)7)259-200(327)150(97-171(301)302)263-205(332)155(109-281)269-212(339)175(119(14)283)273-202(329)147(93-121-47-21-18-22-48-121)264-211(338)174(118(13)282)270-164(289)103-236-179(306)136(64-70-166(291)292)241-163(288)102-234-178(305)125(224)95-123-99-230-110-238-123/h17-24,45-50,98-99,110-119,125,127-158,172-175,232,277-283H,16,25-44,51-97,100-109,216-224H2,1-15H3,(H2,225,284)(H2,226,285)(H2,227,303)(H,230,238)(H,233,286)(H,234,305)(H,235,307)(H,236,306)(H,237,308)(H,239,287)(H,240,309)(H,241,288)(H,242,310)(H,243,311)(H,244,312)(H,245,313)(H,246,314)(H,247,323)(H,248,330)(H,249,331)(H,250,315)(H,251,319)(H,252,320)(H,253,322)(H,254,318)(H,255,336)(H,256,337)(H,257,317)(H,258,326)(H,259,327)(H,260,324)(H,261,321)(H,262,316)(H,263,332)(H,264,338)(H,265,333)(H,266,325)(H,267,334)(H,268,335)(H,269,339)(H,270,289)(H,271,304)(H,272,328)(H,273,329)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H4,228,229,231)/t115-,116-,117-,118+,119+,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,172-,173-,174-,175-/m0/s1 InChIKey XVVOERDUTLJJHN-IAEQDCLQSA-N SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O Roles Classification Chemical Role(s): Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound ) Biological Role(s): glucagon-like peptide-1 receptor agonist An agonist that binds to and activates glucagon-like peptide-1 (GLP-1) receptors. Application(s): neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. hypoglycemic agent A drug which lowers the blood glucose level. View more via ChEBI Ontology ChEBI Ontology Outgoing lixisenatide (CHEBI:85662) has role glucagon-like peptide-1 receptor agonist (CHEBI:71196) lixisenatide (CHEBI:85662) has role hypoglycemic agent (CHEBI:35526) lixisenatide (CHEBI:85662) has role neuroprotective agent (CHEBI:63726) lixisenatide (CHEBI:85662) is a peptidyl amide (CHEBI:15722) lixisenatide (CHEBI:85662) is a polypeptide (CHEBI:15841) IUPAC Name L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysyl-L-lysyl-L-lysinamide INNs Sources lixisenatida WHO MedNet lixisenatide WHO MedNet lixisénatide WHO MedNet lixisenatidum WHO MedNet Synonyms Sources AQVE-10010 ChemIDplus AVE 0010 ChemIDplus AVE0010 ChemIDplus des-38-proline-exendine-4 (Heloderma suspectum)-(1-39)-peptidylpenta-L-lysyl-L-lysinamide ChemIDplus DesPro38Exendin-4(1-39)-Lys6-NH2 ChemIDplus H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2 ChEBI H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2 ChEBI H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH2 ChEBI H-L-His-Gly-L-Glu-Gly-L-Thr-L-Phe-L-Thr-L-Ser-L-Asp-L-Leu-L-Ser-L-Lys-L-Gln-L-Met-L-Glu-L-Glu-L-Glu-L-Ala-L-Val-L-Arg-L-Leu-L-Phe-L-Ile-L-Glu-L-Trp-L-Leu-L-Lys-L-Asn-Gly-Gly-L-Pro-L-Ser-L-Ser-Gly-L-Ala-L-Pro-L-Pro-L-Ser-L-Lys-L-Lys-L-Lys-L-Lys-L-Lys-L-Lys-NH2 ChEBI ZP 10 ChemIDplus ZP10A peptide ChemIDplus Brand Names Sources Adlyxin ChEBI Lyxumia ChemIDplus Manual Xrefs Databases 4815 DrugCentral D09729 KEGG DRUG Lixisenatide Wikipedia View more database links Registry Numbers Types Sources 23952540 Reaxys Registry Number Reaxys 320367-13-3 CAS Registry Number ChemIDplus Citations Types Sources 19629885 PubMed citation Europe PMC 21391833 PubMed citation Europe PMC 23537041 PubMed citation Europe PMC 23558600 PubMed citation Europe PMC 23825925 PubMed citation Europe PMC 23992745 PubMed citation Europe PMC 24086950 PubMed citation Europe PMC 24122776 PubMed citation Europe PMC 24363554 PubMed citation Europe PMC 24373190 PubMed citation Europe PMC 24476092 PubMed citation Europe PMC 24583037 PubMed citation Europe PMC 24641271 PubMed citation Europe PMC 24683832 PubMed citation Europe PMC 24876548 PubMed citation Europe PMC 25012990 PubMed citation Europe PMC 25027491 PubMed citation Europe PMC 25055456 PubMed citation Europe PMC 25066229 PubMed citation Europe PMC 25107586 PubMed citation Europe PMC 25115916 PubMed citation Europe PMC 25119443 PubMed citation Europe PMC 25130920 PubMed citation Europe PMC 25195184 PubMed citation Europe PMC 25773712 PubMed citation Europe PMC 25802728 PubMed citation Europe PMC 25853868 PubMed citation Europe PMC 25887358 PubMed citation Europe PMC 25965710 PubMed citation Europe PMC 26342556 PubMed citation Europe PMC 26423184 PubMed citation Europe PMC 26537183 PubMed citation Europe PMC 26594250 PubMed citation Europe PMC 26630143 PubMed citation Europe PMC 26701217 PubMed citation Europe PMC 26770666 PubMed citation Europe PMC 26787264 PubMed citation Europe PMC 26981945 PubMed citation Europe PMC 26981946 PubMed citation Europe PMC 26981947 PubMed citation Europe PMC 27092017 PubMed citation Europe PMC 27222510 PubMed citation Europe PMC 27252787 PubMed citation Europe PMC 27267268 PubMed citation Europe PMC 27284114 PubMed citation Europe PMC 27310712 PubMed citation Europe PMC 27311491 PubMed citation Europe PMC 27319011 PubMed citation Europe PMC 27341040 PubMed citation Europe PMC Last Modified 10 August 2017