CHEBI:183637 - ketanserin tartrate

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ChEBI Name ketanserin tartrate
ChEBI ID CHEBI:183637
Definition The tartrate salt of ketanserin.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C22H22FN3O3.C4H6O6
Net Charge 0
Average Mass 545.520
Monoisotopic Mass 545.18096
InChI InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
InChIKey KMTLTEVOQLMYRS-LREBCSMRSA-N
SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1
Roles Classification
Biological Role(s): serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
cardiovascular drug
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ketanserin tartrate (CHEBI:183637) has part ketanserin(1+) (CHEBI:183638)
ketanserin tartrate (CHEBI:183637) has role α-adrenergic antagonist (CHEBI:37890)
ketanserin tartrate (CHEBI:183637) has role antihypertensive agent (CHEBI:35674)
ketanserin tartrate (CHEBI:183637) has role cardiovascular drug (CHEBI:35554)
ketanserin tartrate (CHEBI:183637) has role geroprotector (CHEBI:176497)
ketanserin tartrate (CHEBI:183637) has role serotonergic antagonist (CHEBI:48279)
ketanserin tartrate (CHEBI:183637) is a tartrate salt (CHEBI:50562)
IUPAC Name
(2R,3R)-2,3-dihydroxybutanedioic acid - 3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione
Synonyms Sources
3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione (2R,3R)-2,3-dihydroxybutanedioate ChEBI
3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate ChEBI
KJK 945 ChEBI
KJK-945 ChemIDplus
R 49945 ChemIDplus
R41468 tartrate ChEBI
Brand Name Source
Sufrexal KEGG DRUG
Manual Xref Database
D08099 KEGG DRUG
View more database links
Registry Number Type Source
83846-83-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1981023 PubMed citation Europe PMC
2257855 PubMed citation Europe PMC
24134630 PubMed citation Europe PMC
26076739 PubMed citation Europe PMC
26404234 PubMed citation Europe PMC
3071460 PubMed citation Europe PMC
3430696 PubMed citation Europe PMC
Last Modified
09 November 2021