CHEBI:177199 - L-817818

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ChEBI Name L-817818
ChEBI ID CHEBI:177199
Definition A benzoindole that is 1H-benzo[g]indole substituted by naphthalen-2-yl and 2-({(2R)-6-amino-1-[(2S)-2-aminopropoxy]-1-oxohexan-2-yl}amino)-2-oxoethyl groups at positions 2 and 3, respectively. It is a selective nonpeptidic agonist of the somatostatin subtype-5 (SST5) receptor with Ki of 0.4 nM.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Sandra Orchard
Supplier Information
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Formula C33H36N4O3
Net Charge 0
Average Mass 536.676
Monoisotopic Mass 536.27874
InChI InChI=1S/C33H36N4O3/c1-21(35)20-40-33(39)29(12-6-7-17-34)36-30(38)19-28-27-16-15-23-9-4-5-11-26(23)32(27)37-31(28)25-14-13-22-8-2-3-10-24(22)18-25/h2-5,8-11,13-16,18,21,29,37H,6-7,12,17,19-20,34-35H2,1H3,(H,36,38)/t21-,29+/m0/s1
InChIKey NFVRGDRCCNEGBS-KCWXNJEJSA-N
SMILES CC(N)COC(=O)C(CCCCN)NC(=O)CC1=C(NC2=C1C=CC1=C2C=CC=C1)C1=CC=C2C=CC=CC2=C1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): somatostatin receptor agonist
An agonist that binds to and activates somatostatin receptors.
Application(s): neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
hypoglycemic agent
A drug which lowers the blood glucose level.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing L-817818 (CHEBI:177199) has role hypoglycemic agent (CHEBI:35526)
L-817818 (CHEBI:177199) has role neuroprotective agent (CHEBI:63726)
L-817818 (CHEBI:177199) has role somatostatin receptor agonist (CHEBI:177023)
L-817818 (CHEBI:177199) is a benzoindole (CHEBI:38111)
L-817818 (CHEBI:177199) is a carboxylic ester (CHEBI:33308)
L-817818 (CHEBI:177199) is a naphthalenes (CHEBI:25477)
L-817818 (CHEBI:177199) is a primary amino compound (CHEBI:50994)
L-817818 (CHEBI:177199) is a secondary carboxamide (CHEBI:140325)
IUPAC Name
(2S)-2-aminopropyl N2-{[2-(naphthalen-2-yl)-1H-benzo[g]indol-3-yl]acetyl}-D-lysinate
Synonyms Sources
(2S)-2-aminopropyl (2R)-6-amino-2-{2-[2-(naphthalen-2-yl)-1H-benzo[g]indol-3-yl]acetamido}hexanoate IUPAC
L 817818 ChEBI
L-817,818 ChEBI
L817818 ChEBI
Manual Xref Database
8112641 ChemSpider
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Registry Number Type Source
217480-27-8 CAS Registry Number SUBMITTER
Citations Waiting for Citations Types Sources
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Last Modified
05 August 2021