CHEBI:192744 - lobaplatin

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ChEBI Name lobaplatin
ChEBI ID CHEBI:192744
Definition A 1:1 diastereomeric mixture comprising of R,R,S and S,S,S configuration of platinum(II) complexes with 1,2-bis(aminomethyl)cyclobutane as the carrier ligand and lactate as the leaving group. It is a third-generation platinum anticancer drug approved in China for the treatment of chronic myelogenous leukaemia, inoperable metastatic breast cancer and small cell lung cancer.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Stan Laulederkind
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Roles Classification
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
cross-linking reagent
A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified.
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ChEBI Ontology
Outgoing lobaplatin (CHEBI:192744) has part (R,R,S)-lobaplatin (CHEBI:194425)
lobaplatin (CHEBI:192744) has part (S,S,S)-lobaplatin (CHEBI:194426)
lobaplatin (CHEBI:192744) has role antineoplastic agent (CHEBI:35610)
lobaplatin (CHEBI:192744) has role apoptosis inducer (CHEBI:68495)
lobaplatin (CHEBI:192744) has role cross-linking reagent (CHEBI:50684)
lobaplatin (CHEBI:192744) is a diastereoisomeric mixture (CHEBI:60915)
lobaplatin (CHEBI:192744) is a platinum coordination entity (CHEBI:33862)
INNs Sources
lobaplatin WHO MedNet
lobaplatine WHO MedNet
lobaplatino WHO MedNet
lobaplatinum WHO MedNet
Synonyms Sources
1,2-diamino-methylcyclobutane platinum(II) lactate SUBMITTER
1,2-diamino-methylcyclobutane-platinum(II) lactate ChEBI
[2-hydroxypropanoato(2−)-O1,O2][1,2-cyclobutanedimethanamine-N,N']platinum(II) ChEBI
D 19466 ChEBI
D-19466 SUBMITTER
D19466 ChEBI
Manual Xrefs Databases
DB13049 DrugBank
Lobaplatin Wikipedia
View more database links
Registry Number Type Source
135558-11-1 CAS Registry Number ChemIDplus
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Last Modified
21 February 2023