CHEBI:31262 - benserazide hydrochloride

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ChEBI Name benserazide hydrochloride
ChEBI ID CHEBI:31262
Definition A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C10H16ClN3O5
Net Charge 0
Average Mass 293.70400
Monoisotopic Mass 293.07785
InChI InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
InChIKey ULFCBIUXQQYDEI-UHFFFAOYSA-N
SMILES Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O
Roles Classification
Biological Role(s): EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of aromatic-L-amino-acid decarboxylase (EC 4.1.1.28).
dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Application(s): antiparkinson drug
A drug used in the treatment of Parkinson's disease.
dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
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ChEBI Ontology
Outgoing benserazide hydrochloride (CHEBI:31262) has part benserazide(1+) (CHEBI:64190)
benserazide hydrochloride (CHEBI:31262) has role antiparkinson drug (CHEBI:48407)
benserazide hydrochloride (CHEBI:31262) has role dopaminergic agent (CHEBI:48560)
benserazide hydrochloride (CHEBI:31262) has role EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor (CHEBI:59321)
benserazide hydrochloride (CHEBI:31262) is a hydrochloride (CHEBI:36807)
IUPAC Name
2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
Synonyms Sources
2'-(2,3,4-trihydroxybenzyl)-DL-serinohydrazide monohydrochloride ChemIDplus
3-hydroxy-1-oxo-1-[2-(2,3,4-trihydroxybenzyl)hydrazinyl]propan-2-aminium chloride IUPAC
benserazide HCl ChemIDplus
DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride ChemIDplus
Ro 4-4602/001 ChemIDplus
Manual Xref Database
D01653 KEGG DRUG
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Registry Numbers Types Sources
14919-77-8 CAS Registry Number KEGG DRUG
14919-77-8 CAS Registry Number ChemIDplus
6494463 Reaxys Registry Number Reaxys
Last Modified
15 March 2012