Ru360 (CHEBI:194100)

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ChEBI Name	Ru360

ChEBI ID	CHEBI:194100

Definition	A binuclear oxo-bridged Ru compound that selectively inhibits mitochondrial calcium uniporter mediated Ca²⁺-uptake with nanomolar potency in cells.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	TheOtherDave

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Formula

C2H26N8O5Ru2.Cl.Cl.Cl

Net Charge

Average Mass

550.770

Monoisotopic Mass

550.91512

InChI

InChI=1S/2CH2O2.3ClH.8H3N.O.2Ru/c2*2-1-3;;;;;;;;;;;;;;/h2*1H,(H,2,3);3*1H;8*1H3;;;/q;;;;;;;;;;;;;;2*+5/p-5

InChIKey

GAQYLINTMDTWDS-UHFFFAOYSA-I

SMILES

[Cl-].[Cl-].[Cl-].[H]C(=O)O[Ru]([NH3+])([NH3+])([NH3+])([NH3+])O[Ru]([NH3+])([NH3+])([NH3+])([NH3+])OC([H])=O

Roles Classification
Biological Role(s):	mitochondrial calcium uniporter inhibitor Any inhibitor of mitochondrial calcium uniporter. calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.

Application(s):	cardioprotective agent Any protective agent that is able to prevent damage to the heart.

ChEBI Ontology
Outgoing	Ru360 (CHEBI:194100) has role calcium channel blocker (CHEBI:38215) Ru360 (CHEBI:194100) has role cardioprotective agent (CHEBI:77307) Ru360 (CHEBI:194100) has role mitochondrial calcium uniporter inhibitor (CHEBI:194181) Ru360 (CHEBI:194100) is a ruthenium coordination entity (CHEBI:35733)

Registry Number	Type	Source
133399-54-9	CAS Registry Number	ChEBI

Last Modified

23 December 2022