CHEBI:81468 - 5α-dihydrodeoxycorticosterone

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ChEBI Name 5α-dihydrodeoxycorticosterone
ChEBI ID CHEBI:81468
ChEBI ASCII Name 5alpha-dihydrodeoxycorticosterone
Definition A 3-oxo-5α-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H32O3
Net Charge 0
Average Mass 332.484
Monoisotopic Mass 332.23514
InChI InChI=1S/C21H32O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13,15-18,22H,3-12H2,1-2H3/t13-,15-,16-,17-,18+,20-,21-/m0/s1
InChIKey USPYDUPOCUYHQL-KVHKMPIWSA-N
SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)CO
Roles Classification
Biological Role(s): progesterone receptor agonist
A hormone agonist that binds to and activates progesterone receptors.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
Application(s): progesterone receptor agonist
A hormone agonist that binds to and activates progesterone receptors.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 5α-dihydrodeoxycorticosterone (CHEBI:81468) has functional parent 11-deoxycorticosterone (CHEBI:16973)
5α-dihydrodeoxycorticosterone (CHEBI:81468) has parent hydride 5α-pregnane (CHEBI:20656)
5α-dihydrodeoxycorticosterone (CHEBI:81468) has role anticonvulsant (CHEBI:35623)
5α-dihydrodeoxycorticosterone (CHEBI:81468) has role GABA modulator (CHEBI:50268)
5α-dihydrodeoxycorticosterone (CHEBI:81468) has role progesterone receptor agonist (CHEBI:70709)
5α-dihydrodeoxycorticosterone (CHEBI:81468) is a 20-oxo steroid (CHEBI:36885)
5α-dihydrodeoxycorticosterone (CHEBI:81468) is a 21-hydroxy steroid (CHEBI:35344)
5α-dihydrodeoxycorticosterone (CHEBI:81468) is a 3-oxo-5α-steroid (CHEBI:13601)
5α-dihydrodeoxycorticosterone (CHEBI:81468) is a mineralocorticoid (CHEBI:25354)
5α-dihydrodeoxycorticosterone (CHEBI:81468) is a primary α-hydroxy ketone (CHEBI:139590)
IUPAC Name
21-hydroxy-5α-pregnane-3,20-dione
Synonyms Sources
(5α)-21-hydroxypregnane-3,20-dione ChEBI
5α-dihydro-11-deoxycorticosterone ChemIDplus
5α-dihydrodeoxycorticosterone UniProt
5α-pregnan-21-ol-3,20-dione KEGG COMPOUND
allopregnane-21-ol-3,20-dione KEGG COMPOUND
Manual Xrefs Databases
4953958 ChemSpider
C18040 KEGG COMPOUND
Dihydrodeoxycorticosterone Wikipedia
HMDB0060407 HMDB
LMST02030134 LIPID MAPS
View more database links
Registry Number Type Source
298-36-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11978855 PubMed citation Europe PMC
11995921 PubMed citation Europe PMC
16393154 PubMed citation Europe PMC
23246684 PubMed citation Europe PMC
3617115 PubMed citation Europe PMC
54171 PubMed citation Europe PMC
744157 PubMed citation Europe PMC
Last Modified
16 September 2021