flutrimazole (CHEBI:82864)

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ChEBI Name	flutrimazole

ChEBI ID	CHEBI:82864

Definition	An imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Toni Morrison

Supplier Information

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Formula

C22H16F2N2

Net Charge

Average Mass

346.37260

Monoisotopic Mass

346.12815

InChI

InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

InChIKey

QHMWCHQXCUNUAK-UHFFFAOYSA-N

SMILES

Fc1ccc(cc1)C(c1ccccc1)(c1ccccc1F)n1ccnc1

Roles Classification
Biological Role(s):	EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14alpha-demethylase). antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. (via imidazole antifungal drug ) antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. (via imidazole antifungal agent )

Application(s):	antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. (via imidazole antifungal drug )

ChEBI Ontology
Outgoing	flutrimazole (CHEBI:82864) has role EC 1.14.13.70 (sterol 14α-demethylase) inhibitor (CHEBI:77884) flutrimazole (CHEBI:82864) is a imidazole antifungal drug (CHEBI:87069) flutrimazole (CHEBI:82864) is a imidazoles (CHEBI:24780) flutrimazole (CHEBI:82864) is a monofluorobenzenes (CHEBI:83575)

IUPAC Name

1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole

Synonyms	Sources
1-(2,4'-difluorotrityl)imidazole	ChEBI
1-(o-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole	ChemIDplus

Last Modified

22 February 2017