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> Main
CHEBI:39980 - 3-hydroxyglutaric acid
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ChEBI Name
3-hydroxyglutaric acid
ChEBI ID
CHEBI:39980
Definition
A 3 hydroxy carboxylic acid that is glutaric acid which is substituted by a hydroxy group at position 3. It is a diagnostic marker for glutaric aciduria type I.
Stars
This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Molfile
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Formula
C5H8O5
Net Charge
0
Average Mass
148.114
Monoisotopic Mass
148.03717
InChI
InChI=1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)
InChIKey
ZQHYXNSQOIDNTL-UHFFFAOYSA-N
SMILES
C(CC(CC(=O)O)O)(=O)O
Metabolite of Species
Details
Homo sapiens
(NCBI:txid9606)
Found in blood
(UBERON:0000178)
. See:
PubMed
Homo sapiens
(NCBI:txid9606)
Found in cerebrospinal fluid
(UBERON:0001359)
. See:
PubMed
Homo sapiens
(NCBI:txid9606)
Found in blood plasma
(BTO_0000131)
. See:
PubMed
Homo sapiens
(NCBI:txid9606)
Found in urine
(BTO:0001419)
. See:
PubMed
Roles Classification
Chemical Role
(s):
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Br
o
nsted base).
(via
oxoacid
)
Biological Role
(s):
human urinary metabolite
Any metabolite (endogenous or exogenous) found in human urine samples.
human blood serum metabolite
Any metabolite (endogenous or exogenous) found in human blood serum samples.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
3-hydroxyglutaric acid (
CHEBI:39980
)
has functional parent
glutaric acid (
CHEBI:17859
)
3-hydroxyglutaric acid (
CHEBI:39980
)
has role
human blood serum metabolite (
CHEBI:85234
)
3-hydroxyglutaric acid (
CHEBI:39980
)
has role
human urinary metabolite (
CHEBI:84087
)
3-hydroxyglutaric acid (
CHEBI:39980
)
is a
α,ω-dicarboxylic acid (
CHEBI:28383
)
3-hydroxyglutaric acid (
CHEBI:39980
)
is a
3-hydroxy carboxylic acid (
CHEBI:61355
)
3-hydroxyglutaric acid (
CHEBI:39980
)
is conjugate acid of
3-hydroxyglutarate(2−) (
CHEBI:191379
)
Incoming
3-hydroxyglutarate(2−) (
CHEBI:191379
)
is conjugate base of
3-hydroxyglutaric acid (
CHEBI:39980
)
IUPAC Name
3-hydroxypentanedioic acid
Synonyms
Sources
3-hydroxy-glutaric acid
HMDB
β-hydroxyglutaric acid
ChEBI
Manual Xrefs
Databases
158277
ChemSpider
3HG
PDBeChem
DB04594
DrugBank
FDB022040
FooDB
HMDB0000428
HMDB
View more database links
Registry Numbers
Types
Sources
1705476
Reaxys Registry Number
Reaxys
638-18-6
CAS Registry Number
ChemIDplus
Citations
Types
Sources
10066389
PubMed citation
Europe PMC
10604139
PubMed citation
Europe PMC
11597592
PubMed citation
Europe PMC
11768583
PubMed citation
Europe PMC
14598231
PubMed citation
Europe PMC
14693719
PubMed citation
Europe PMC
15262270
PubMed citation
Europe PMC
15505388
PubMed citation
Europe PMC
15702406
PubMed citation
Europe PMC
16055049
PubMed citation
Europe PMC
16111821
PubMed citation
Europe PMC
16330550
PubMed citation
Europe PMC
16439578
PubMed citation
Europe PMC
16573641
PubMed citation
Europe PMC
1986098
PubMed citation
Europe PMC
20978942
PubMed citation
Europe PMC
29098534
PubMed citation
Europe PMC
30218917
PubMed citation
Europe PMC
30570710
PubMed citation
Europe PMC
30686684
PubMed citation
Europe PMC
31240164
PubMed citation
Europe PMC
9266362
PubMed citation
Europe PMC
Last Modified
09 May 2022