CHEBI:194147 - aristolochic acids

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ChEBI Name aristolochic acids
ChEBI ID CHEBI:194147
Definition Organic heterotetracyclic compounds which are a group of nitro phenanthrene organic acids, naturally found in many kinds of plants, such as Aristolochia and Asarum, and widely cultivated in Asia.They are identified as a class 1 human carcinogen by the International Agency for Research on Cancer owing to their carcinogenicity and nephrotoxicity and can pose a significant hazard to food safety and human health.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H6NO6
Net Charge 0
Average Mass (excl. R groups) 308.223
Monoisotopic Mass (excl. R groups) 308.01951
SMILES OC(=O)C1=CC2=C(OCO2)C2=C1C(=CC1=C2C=C([*])C([*])=C1[*])[N+]([O-])=O
Metabolite of Species Details
Aristolochia (NCBI:txid12947) See: PubMed
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): carcinogenic agent
A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
nephrotoxin
A poison that interferes with the function of the kidneys.
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ChEBI Ontology
Outgoing aristolochic acids (CHEBI:194147) has role carcinogenic agent (CHEBI:50903)
aristolochic acids (CHEBI:194147) has role nephrotoxin (CHEBI:61015)
aristolochic acids (CHEBI:194147) is a C-nitro compound (CHEBI:35716)
aristolochic acids (CHEBI:194147) is a cyclic acetal (CHEBI:59770)
aristolochic acids (CHEBI:194147) is a monocarboxylic acid (CHEBI:25384)
aristolochic acids (CHEBI:194147) is a organic heterotetracyclic compound (CHEBI:38163)
Incoming aristolochic acid A (CHEBI:2825) is a aristolochic acids (CHEBI:194147)
aristolochic acid B (CHEBI:194149) is a aristolochic acids (CHEBI:194147)
aristolochic acid C (CHEBI:194151) is a aristolochic acids (CHEBI:194147)
aristolochic acid D (CHEBI:194152) is a aristolochic acids (CHEBI:194147)
Manual Xref Database
Aristolochic acid Wikipedia
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Citation Waiting for Citations Type Source
36347294 PubMed citation Europe PMC
Last Modified
05 December 2022