CHEBI:231335 - givinostat hydrochloride monohydrate

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ChEBI Name givinostat hydrochloride monohydrate
ChEBI ID CHEBI:231335
Definition The monohydrate form of givinostat hydrochloride. It is a histone deacetylase inhibitor indicated for the treatment of Duchenne muscular dystrophy in patients 6 years of age and older.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C24H27N3O4.H2O.ClH
Net Charge 0
Average Mass 475.970
Monoisotopic Mass 475.18740
InChI InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2
InChIKey FKGKZBBDJSKCIS-UHFFFAOYSA-N
SMILES O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC1=CC=C(C=C1)C(=O)NO)C=C2
Roles Classification
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Application(s): angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
anti-inflammatory agent
Any compound that has anti-inflammatory effects.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing givinostat hydrochloride monohydrate (CHEBI:231335) has part givinostat hydrochloride (CHEBI:231333)
givinostat hydrochloride monohydrate (CHEBI:231335) has role angiogenesis inhibitor (CHEBI:48422)
givinostat hydrochloride monohydrate (CHEBI:231335) has role anti-inflammatory agent (CHEBI:67079)
givinostat hydrochloride monohydrate (CHEBI:231335) has role antineoplastic agent (CHEBI:35610)
givinostat hydrochloride monohydrate (CHEBI:231335) has role apoptosis inducer (CHEBI:68495)
givinostat hydrochloride monohydrate (CHEBI:231335) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
givinostat hydrochloride monohydrate (CHEBI:231335) is a hydrate (CHEBI:35505)
IUPAC Name
{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate
Synonyms Sources
[6-(diethylaminomethyl)naphthalen-2-yl]methyl[4(hydroxycarbamoyl)phenyl]carbamate hydrochloride monohydrate ChEBI
givinostat hydrochloride hydrate KEGG DRUG
{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate—hydrogen chloride—water (1/1/1) IUPAC
Brand Name Source
Duvyzat KEGG DRUG
Manual Xrefs Databases
D12743 KEGG DRUG
DBSALT003496 DrugBank
View more database links
Registry Number Type Source
732302-99-7 CAS Registry Number KEGG DRUG
Last Modified
08 May 2024