oviedomycin (CHEBI:156291)

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ChEBI Name	oviedomycin

ChEBI ID	CHEBI:156291

Definition	A member of the class of tetraphenes that is 1,4,7,12-tetrahydrotetraphene substituted by oxo groups at positions 1, 4, 7, and 12, by hydroxy groups at positions 2, 6 and 8, and by a methyl group at position 3. It is a natural product found in Streptomyces antibioticus ATCC 11891 which exhibits cytotoxicity against A549 human lung cancer cells, HepG2 liver cancer cells, and MCF-7 breast cancer cells.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Martin Larralde

Supplier Information

Download	Molfile XML SDF

Formula

C19H10O7

Net Charge

Average Mass

350.282

Monoisotopic Mass

350.04265

InChI

InChI=1S/C19H10O7/c1-6-15(22)8-5-10(21)13-14(12(8)19(26)16(6)23)17(24)7-3-2-4-9(20)11(7)18(13)25/h2-5,20-21,23H,1H3

InChIKey

LRVJUCBWMNTDLP-UHFFFAOYSA-N

SMILES

CC1=C(O)C(=O)C2=C(C=C(O)C3=C2C(=O)C2=CC=CC(O)=C2C3=O)C1=O

Metabolite of Species	Details
Streptomyces ansochromogenes (NCBI:txid115647)	See: PubMed
Streptomyces antibioticus (NCBI:txid1890)	of strain ATCC 11891 See: PubMed

Roles Classification
Biological Role(s):	bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. (via angucycline ) antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. (via angucycline antibiotic )

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	oviedomycin (CHEBI:156291) has role antineoplastic agent (CHEBI:35610) oviedomycin (CHEBI:156291) has role bacterial metabolite (CHEBI:76969) oviedomycin (CHEBI:156291) is a p-quinones (CHEBI:25830) oviedomycin (CHEBI:156291) is a angucycline antibiotic (CHEBI:70737) oviedomycin (CHEBI:156291) is a phenols (CHEBI:33853) oviedomycin (CHEBI:156291) is a tetraphenes (CHEBI:51067)

IUPAC Name

2,6,8-trihydroxy-3-methyltetraphene-1,4,7,12-tetrone

Synonyms	Sources
2,6,8-trihydroxy-3-methyl-1,4,7,12-tetrahydrotetraphene-1,4,7,12-tetrone	ChEBI
2,6,8-trihydroxy-3-methyl-benz[a]anthracene-1,4,7,12-tetrone	ChEBI
3-methyl-2,6,8-trihydroxybenzo[a]anthracene-1,4,7,12-tetrone	ChEBI

Registry Number	Type	Source
439127-45-4	CAS Registry Number	KNApSAcK

Last Modified

12 August 2020