1',4-dihydroxymidazolam (CHEBI:145332)

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ChEBI Name	1',4-dihydroxymidazolam

ChEBI ID	CHEBI:145332

Definition	An imidazobenzodiazepine that is midazolam which is substituted by a hydroxy group at positions 2 and 4. It is the minor metabolite of the anesthetic, midazolam.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C18H13ClFN3O2

Net Charge

Average Mass

357.770

Monoisotopic Mass

357.06803

InChI

InChI=1S/C18H13ClFN3O2/c19-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)20)22-18(25)15-8-21-16(9-24)23(14)15/h1-8,18,24-25H,9H2

InChIKey

OJDUJEPGFILARE-UHFFFAOYSA-N

SMILES

C1(=NC(C=2N(C=3C1=CC(=CC3)Cl)C(=NC2)CO)O)C=4C=CC=CC4F

Roles Classification
Biological Role(s):	drug metabolite GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

Application(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

ChEBI Ontology
Outgoing	1',4-dihydroxymidazolam (CHEBI:145332) has functional parent midazolam (CHEBI:6931) 1',4-dihydroxymidazolam (CHEBI:145332) has role drug metabolite (CHEBI:49103) 1',4-dihydroxymidazolam (CHEBI:145332) is a aromatic primary alcohol (CHEBI:33857) 1',4-dihydroxymidazolam (CHEBI:145332) is a imidazobenzodiazepine (CHEBI:142118) 1',4-dihydroxymidazolam (CHEBI:145332) is a monofluorobenzenes (CHEBI:83575) 1',4-dihydroxymidazolam (CHEBI:145332) is a organochlorine compound (CHEBI:36683)

IUPAC Name

8-chloro-6-(2-fluorophenyl)-1-(hydroxymethyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol

Synonyms	Sources
1',4'-dihydroxymidazolam	ChEBI
1',4-dihydroxy midazolam	ChEBI
1,4-dihydroxy midazolam	ChEBI
1,4-dihydroxymidazolam	ChEBI
8-chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol	ChEBI
α,4-dihydroxymidazolam	ChEBI
Ro 21-0284	ChEBI

Registry Number	Type	Source
64740-68-7	CAS Registry Number	ChEBI

Last Modified

11 November 2019