CHEBI:189659 - PF-06446846

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ChEBI Name PF-06446846
ChEBI ID CHEBI:189659
Definition A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Jinyang Du
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Formula C22H20ClN7O
Net Charge 0
Average Mass 433.900
Monoisotopic Mass 433.14179
InChI InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1
InChIKey FDTXHWQFIXYHCL-QGZVFWFLSA-N
SMILES ClC1=CC=CN=C1N([C@@H]1CCCNC1)C(=O)C1=CC=C(C=C1)N1N=NC2=CC=CN=C12
Roles Classification
Biological Role(s): EC 3.4.21.61 (kexin) inhibitor
An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of kexin (EC 3.4.21.61).
Application(s): antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
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ChEBI Ontology
Outgoing PF-06446846 (CHEBI:189659) has role antilipemic drug (CHEBI:35679)
PF-06446846 (CHEBI:189659) has role EC 3.4.21.61 (kexin) inhibitor (CHEBI:189665)
PF-06446846 (CHEBI:189659) is a benzamides (CHEBI:22702)
PF-06446846 (CHEBI:189659) is a monochloropyridine (CHEBI:39172)
PF-06446846 (CHEBI:189659) is a piperidines (CHEBI:26151)
PF-06446846 (CHEBI:189659) is a tertiary carboxamide (CHEBI:140326)
PF-06446846 (CHEBI:189659) is a triazolopyridine (CHEBI:46746)
IUPAC Name
N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide
Synonyms Sources
PF 06446846 ChEBI
PF-06446846 ChEBI
PF-846 ChEBI
PF06446846 ChEBI
Manual Xrefs Databases
74849329 ChemSpider
MVM PDBeChem
US9227956 Patent
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Registry Number Type Source
1632250-49-7 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
28323820 PubMed citation Europe PMC
29878763 PubMed citation Europe PMC
31160784 PubMed citation Europe PMC
31867167 PubMed citation Europe PMC
33009412 PubMed citation Europe PMC
33801308 PubMed citation Europe PMC
34359627 PubMed citation Europe PMC
Last Modified
07 February 2022