CHEBI:228206 - KU-60019

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ChEBI Name KU-60019
ChEBI ID CHEBI:228206
Definition A secondary carboxamide resulting from the formal condensation of the carboxy group of [(2R,6S)-2,6-dimethylmorpholin-4-yl]acetic acid with the amino group of 2-(7-amino-9H-thioxanthen-4-yl)-6-(morpholin-4-yl)-4H-pyran-4-one. It is an ATM kinase inhibitor (IC50 = 6.3 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Wei-Chia Tseng
Secondary ChEBI IDs CHEBI:91416
Supplier Information
Download Molfile XML SDF
Formula C30H33N3O5S
Net Charge 0
Average Mass 547.670
Monoisotopic Mass 547.21409
InChI InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChIKey SCELLOWTHJGVIC-BGYRXZFFSA-N
SMILES C[C@H]1CN(CC(=O)NC2=CC3=C(SC4=C(C3)C=CC=C4C3=CC(=O)C=C(O3)N3CCOCC3)C=C2)C[C@@H](C)O1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): autophagy inducer
Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
Application(s): radiosensitizing agent
A drug that makes increases the sensitivity of tumour cells to radiation therapy.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing KU-60019 (CHEBI:228206) has role antineoplastic agent (CHEBI:35610)
KU-60019 (CHEBI:228206) has role autophagy inducer (CHEBI:138880)
KU-60019 (CHEBI:228206) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
KU-60019 (CHEBI:228206) has role radiosensitizing agent (CHEBI:132992)
KU-60019 (CHEBI:228206) is a 4-pyranones (CHEBI:131906)
KU-60019 (CHEBI:228206) is a morpholines (CHEBI:38785)
KU-60019 (CHEBI:228206) is a secondary carboxamide (CHEBI:140325)
KU-60019 (CHEBI:228206) is a tertiary amino compound (CHEBI:50996)
KU-60019 (CHEBI:228206) is a thioxanthenes (CHEBI:50930)
IUPAC Name
2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-N-{5-[6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl}acetamide
Synonyms Sources
KU 60019 ChEBI
KU60019 ChEBI
Manual Xref Database
LSM-1156 LINCS
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Registry Numbers Types Sources
925701-46-8 CAS Registry Number ChEBI
925701-49-1 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
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Last Modified
14 November 2023