CHEBI:66385 - michellamine A

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ChEBI Name michellamine A
ChEBI ID CHEBI:66385
Definition A dimeric isoquinoline alkaloid isolated from Ancistrocladus abbreviatus and has been shown to exhibit anti-HIV activity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C46H48N2O8
Net Charge 0
Average Mass 756.88190
Monoisotopic Mass 756.34107
InChI InChI=1S/C46H48N2O8/c1-19-9-25-27(41-31-13-21(3)47-23(5)39(31)33(49)17-35(41)51)15-29(45(53)43(25)37(11-19)55-7)30-16-28(26-10-20(2)12-38(56-8)44(26)46(30)54)42-32-14-22(4)48-24(6)40(32)34(50)18-36(42)52/h9-12,15-18,21-24,47-54H,13-14H2,1-8H3/t21-,22-,23-,24-/m0/s1
InChIKey GMLBVLXDRNJFGR-ZJZGAYNASA-N
SMILES COc1cc(C)cc2c(cc(c(O)c12)-c1cc(-c2c(O)cc(O)c3[C@H](C)N[C@@H](C)Cc23)c2cc(C)cc(OC)c2c1O)-c1c(O)cc(O)c2[C@H](C)N[C@@H](C)Cc12
Metabolite of Species Details
Ancistrocladus abbreviatus (NCBI:txid122295) Found in aerial part (BTO:0001658). See: PubMed
Roles Classification
Biological Role(s): anti-HIV-2 agent
An anti-HIV agent that destroys or inhibits the replication of HIV-2, the less infective and less virulent of the two types of HIV virus.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
anti-HIV-1 agent
An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing michellamine A (CHEBI:66385) has role anti-HIV-1 agent (CHEBI:64947)
michellamine A (CHEBI:66385) has role anti-HIV-2 agent (CHEBI:64949)
michellamine A (CHEBI:66385) has role metabolite (CHEBI:25212)
michellamine A (CHEBI:66385) is a aromatic ether (CHEBI:35618)
michellamine A (CHEBI:66385) is a isoquinoline alkaloid (CHEBI:24921)
michellamine A (CHEBI:66385) is a isoquinolines (CHEBI:24922)
michellamine A (CHEBI:66385) is a methoxynaphthalene (CHEBI:48851)
michellamine A (CHEBI:66385) is a naphthols (CHEBI:25392)
michellamine A (CHEBI:66385) is a polyphenol (CHEBI:26195)
michellamine A (CHEBI:66385) is a ring assembly (CHEBI:36820)
IUPAC Name
(1S,3S,1'S,3'S)-5,5'-(1,1'-dihydroxy-8,8'-dimethoxy-6,6'-dimethyl-2,2'-binaphthalene-4,4'-diyl)bis(1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol)
Registry Numbers Types Sources
137793-81-8 CAS Registry Number ChemIDplus
6630823 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10368651 PubMed citation Europe PMC
1766007 PubMed citation Europe PMC
Last Modified
15 April 2013
General Comment
2013-04-15 An atropisomer of michellamine B.