CHEBI:195522 - KuFal194

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ChEBI Name KuFal194
ChEBI ID CHEBI:195522
Definition An indoloquinoline that is 11H-indolo[3,2-c]quinoline substituted by carboxy and iodo groups at positions 6 and 10, respectively. It is a potent inhibitor of DYRK1A (IC50 = 6 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Doug Howe
Supplier Information
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Formula C16H9IN2O2
Net Charge 0
Average Mass 388.164
Monoisotopic Mass 387.97087
InChI InChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12-14(19-13(9)10)8-4-1-2-7-11(8)18-15(12)16(20)21/h1-7,19H,(H,20,21)
InChIKey SDRAETFVRBBLOB-UHFFFAOYSA-N
SMILES OC(=O)C1=NC2=CC=CC=C2C2=C1C1=C(N2)C(I)=CC=C1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): EC 2.7.12.1 (dual-specificity kinase) inhibitor
An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of dual-specificity kinase (EC 2.7.12.1).
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ChEBI Ontology
Outgoing KuFal194 (CHEBI:195522) has role EC 2.7.12.1 (dual-specificity kinase) inhibitor (CHEBI:195525)
KuFal194 (CHEBI:195522) is a indoloquinoline (CHEBI:195524)
KuFal194 (CHEBI:195522) is a monocarboxylic acid (CHEBI:25384)
KuFal194 (CHEBI:195522) is a organoiodine compound (CHEBI:37142)
IUPAC Name
10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid
Synonyms Sources
Dyrk1A-IN-5 ChEBI
KuFal 194 ChEBI
KuFal-194 ChEBI
Manual Xref Database
4E1 PDBeChem
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Registry Number Type Source
1685235-41-9 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
25730262 PubMed citation Europe PMC
29364148 PubMed citation Europe PMC
34090874 PubMed citation SUBMITTER
34954592 PubMed citation Europe PMC
Last Modified
03 August 2023