A pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo.
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This entity has been manually annotated by the ChEBI Team.
4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol
(CHEBI:64110)
has role
estrogen receptor agonist
(CHEBI:63951)
4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol
(CHEBI:64110)
is a
phenols
(CHEBI:33853)
4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol
(CHEBI:64110)
is a
pyrazoles
(CHEBI:26410)