| nadolol |
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| CHEBI:7444 |
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| Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol. |
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This entity has been manually annotated by the ChEBI Team.
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sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
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anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
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View more via ChEBI Ontology
rac- (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
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1-(tert-butylamino)-3-[(5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy]-2-propanol
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ChEBI
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2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol
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ChemIDplus
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Corgard
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KEGG DRUG
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Solgol
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ChEBI
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2508986
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Beilstein Registry Number
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Beilstein
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42200-33-9
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CAS Registry Number
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ChemIDplus
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42200-33-9
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CAS Registry Number
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NIST Chemistry WebBook
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 2011-01-10
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A non-cardioselective beta-blocker, nadolol is used in the management of cardiac arrhythmias, angina pectoris, and hypertension. It is also used in the prophylactic treatment of migraine, and as an adjunct in the treatment of hyperthyroidism.
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2011-01-10
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Nadolol is administered as an equimolar mixture of the four possible 2,3-cis-diastereoisomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol; the 2R,3S,2'R-isomer is the most active.
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