CHEBI:145810 - insulin

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name insulin
ChEBI ID CHEBI:145810
Definition A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the β cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies.
Stars This entity has been manually annotated by the ChEBI Team.
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via peptide hormone )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing insulin (CHEBI:145810) is a heterodetic cyclic peptide (CHEBI:24533)
insulin (CHEBI:145810) is a peptide hormone (CHEBI:25905)
insulin (CHEBI:145810) is a polypeptide (CHEBI:15841)
Incoming insulin (human) (CHEBI:5931) is a insulin (CHEBI:145810)
Manual Xref Database
Insulin Wikipedia
View more database links
Citations Waiting for Citations Types Sources
12137720 PubMed citation Europe PMC
19251032 PubMed citation Europe PMC
25848166 PubMed citation Europe PMC
5941964 PubMed citation Europe PMC
6069707 PubMed citation Europe PMC
Last Modified
16 January 2020
General Comment
2020-01-16 This entry is for insulin which is not species specific.