PD-146176 (CHEBI:173098)

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ChEBI Name	PD-146176

ChEBI ID	CHEBI:173098

Definition	An organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

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Formula

C15H11NS

Net Charge

Average Mass

237.320

Monoisotopic Mass

237.06122

InChI

InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

InChIKey

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

SMILES

C1SC2=CC=CC=C2C2=C1C1=C(N2)C=CC=C1

Roles Classification
Biological Role(s):	ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33).

Application(s):	antiatherogenic agent A cardiovascular drug that prevents atherogenesis, the accumulation of lipid-containing plaques on the innermost layers of the arteries. Compare with antiatherosclerotic agent.

ChEBI Ontology
Outgoing	PD-146176 (CHEBI:173098) has role antiatherogenic agent (CHEBI:50855) PD-146176 (CHEBI:173098) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996) PD-146176 (CHEBI:173098) has role ferroptosis inhibitor (CHEBI:173084) PD-146176 (CHEBI:173098) is a organic heterotetracyclic compound (CHEBI:38163) PD-146176 (CHEBI:173098) is a organonitrogen heterocyclic compound (CHEBI:38101) PD-146176 (CHEBI:173098) is a organosulfur heterocyclic compound (CHEBI:38106)

IUPAC Name

6,11-dihydrothiochromeno[4,3-b]indole

Synonyms	Sources
6,11-dihydro[1]benzothiopyrano[4,3-b]indole	IUPAC
PD 146176	ChemIDplus
PD146176	ChEBI

Registry Number	Type	Source
4079-26-9	CAS Registry Number	ChemIDplus

Last Modified

27 May 2021