CHEBI:29506 - cethromycin

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ChEBI Name cethromycin
ChEBI ID CHEBI:29506
Definition A macrolide antibiotic which displays in vitro activity against both gram-positive and gram-negative bacteria and is currently under investigation for the treatment of community-acquired pneumonia. The US Food and Drug Administration (FDA) have also granted orphan drug designation to cethromycin for the treatment of anthrax prophylaxis, tularemia, and plague (PDB entry: 1NWX).
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:40317
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Formula C42H59N3O10
Net Charge 0
Average Mass 765.945
Monoisotopic Mass 765.42005
InChI InChI=1S/C42H59N3O10/c1-11-32-42(8)36(44-40(50)55-42)25(4)33(46)23(2)21-41(7,51-18-14-15-28-20-29-16-12-13-17-30(29)43-22-28)37(26(5)34(47)27(6)38(49)53-32)54-39-35(48)31(45(9)10)19-24(3)52-39/h12-17,20,22-27,31-32,35-37,39,48H,11,18-19,21H2,1-10H3,(H,44,50)/t23-,24-,25+,26+,27-,31+,32-,35-,36-,37-,39+,41-,42-/m1/s1
InChIKey PENDGIOBPJLVBT-AMXFZXBBSA-N
SMILES [C@@H]1(O[C@@H]2[C@H](C(=O)[C@H](C(O[C@@H]([C@@]3([C@H](NC(=O)O3)[C@H](C(=O)[C@H](C)C[C@]2(OCC(=C(C4=CC5=C(N=C4)C=CC=C5)[H])[H])C)C)C)CC)=O)C)C)O[C@@H](C[C@@H]([C@H]1O)N(C)C)C
Roles Classification
Biological Role(s): antibacterial drug
A drug used to treat or prevent bacterial infections.
protein synthesis inhibitor
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via macrolide antibiotic )
Application(s): antibacterial drug
A drug used to treat or prevent bacterial infections.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing cethromycin (CHEBI:29506) has role antibacterial drug (CHEBI:36047)
cethromycin (CHEBI:29506) has role protein synthesis inhibitor (CHEBI:48001)
cethromycin (CHEBI:29506) is a macrolide antibiotic (CHEBI:25105)
cethromycin (CHEBI:29506) is a monosaccharide derivative (CHEBI:63367)
cethromycin (CHEBI:29506) is a quinolines (CHEBI:26513)
IUPAC Name
(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-11-{[3-(quinolin-3-yl)prop-2-en-1-yl]oxy}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
INNs Sources
cethromycin WHO MedNet
céthromycine WHO MedNet
cethromycinum WHO MedNet
cetromicina WHO MedNet
Synonyms Sources
A-195773 KEGG COMPOUND
Abbott-195773 KEGG COMPOUND
ABT-773 KEGG COMPOUND
Brand Name Source
Restanza DrugBank
Manual Xrefs Databases
773 PDBeChem
C12020 KEGG COMPOUND
Cethromycin Wikipedia
D02391 KEGG DRUG
DB06419 DrugBank
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Registry Numbers Types Sources
205110-48-1 CAS Registry Number KEGG COMPOUND
205110-48-1 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10639382 PubMed citation Europe PMC
12623020 PubMed citation Europe PMC
12805263 PubMed citation Europe PMC
15380262 PubMed citation Europe PMC
17324007 PubMed citation Europe PMC
18321237 PubMed citation Europe PMC
20180612 PubMed citation Europe PMC
21859946 PubMed citation Europe PMC
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Last Modified
13 September 2019