CHEBI:62882 - IWR-1-endo

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ChEBI Name IWR-1-endo
ChEBI ID CHEBI:62882
ChEBI ASCII Name IWR-1-endo
Definition A dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
Supplier Information
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Formula C25H19N3O3
Net Charge 0
Average Mass 409.438
Monoisotopic Mass 409.14264
InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
InChIKey ZGSXEXBYLJIOGF-ALFLXDJESA-N
SMILES [C@@]12([C@H]3C=C[C@@H]([C@]1(C(N(C2=O)C=4C=CC(=CC4)C(NC=5C6=C(C=CC5)C=CC=N6)=O)=O)[H])C3)[H]
Roles Classification
Biological Role(s): Wnt signalling inhibitor
A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
axin stabilizer
Any compound that stabilizes axin proteins.
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ChEBI Ontology
Outgoing IWR-1-endo (CHEBI:62882) has role axin stabilizer (CHEBI:62914)
IWR-1-endo (CHEBI:62882) has role Wnt signalling inhibitor (CHEBI:78031)
IWR-1-endo (CHEBI:62882) is a benzamides (CHEBI:22702)
IWR-1-endo (CHEBI:62882) is a bridged compound (CHEBI:35990)
IWR-1-endo (CHEBI:62882) is a dicarboximide (CHEBI:35356)
IWR-1-endo (CHEBI:62882) is a quinolines (CHEBI:26513)
IUPAC Name
4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide
Synonym Source
IRW1 SUBMITTER
Manual Xrefs Databases
LSM-5707 LINCS
WO2009155001 Patent
View more database links
Registry Number Type Source
19908763 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
19125156 PubMed citation SUBMITTER
19410457 PubMed citation Europe PMC
19759537 PubMed citation SUBMITTER
25963533 PubMed citation Europe PMC
26141761 PubMed citation Europe PMC
26214410 PubMed citation Europe PMC
26549292 PubMed citation Europe PMC
Last Modified
06 July 2016