CHEBI:229970 - CM-272

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ChEBI Name CM-272
ChEBI ID CHEBI:229970
Definition A member of the class of aminoquinolines that is is quinoline substituted by 5-methylfuran-2-yl, (1-methylpiperidin-4-yl)amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a dual G9a/DNA methyltransferases inhibitor with antitumor activity. It inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP (IC50 = 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Jonathan Muyskens
Supplier Information
Download Molfile XML SDF
Formula C28H38N4O3
Net Charge 0
Average Mass 478.637
Monoisotopic Mass 478.29439
InChI InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30)
InChIKey RLQLKZTYUYIWDB-UHFFFAOYSA-N
SMILES COC1=C(OCCCN2CCCC2)C=C2N=C(C=C(NC3CCN(C)CC3)C2=C1)C1=CC=C(C)O1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
ferroptosis inducer
Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor
An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of Enhancer of zeste homolog 2 (EZH2), a histone-lysine N-methyltransferase (EC 2.1.1.43).
EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor
An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing CM-272 (CHEBI:229970) has role antineoplastic agent (CHEBI:35610)
CM-272 (CHEBI:229970) has role apoptosis inducer (CHEBI:68495)
CM-272 (CHEBI:229970) has role EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor (CHEBI:90190)
CM-272 (CHEBI:229970) has role EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor (CHEBI:167694)
CM-272 (CHEBI:229970) has role ferroptosis inducer (CHEBI:173085)
CM-272 (CHEBI:229970) is a N-alkylpyrrolidine (CHEBI:46775)
CM-272 (CHEBI:229970) is a aminoquinoline (CHEBI:36709)
CM-272 (CHEBI:229970) is a aromatic ether (CHEBI:35618)
CM-272 (CHEBI:229970) is a diether (CHEBI:46786)
CM-272 (CHEBI:229970) is a furans (CHEBI:24129)
CM-272 (CHEBI:229970) is a piperidines (CHEBI:26151)
CM-272 (CHEBI:229970) is a secondary amino compound (CHEBI:50995)
CM-272 (CHEBI:229970) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine
Synonyms Sources
6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine ChEBI
CM 272 ChEBI
CM272 ChEBI
Registry Number Type Source
1846570-31-7 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
28548080 PubMed citation Europe PMC
29953809 PubMed citation Europe PMC
30014490 PubMed citation Europe PMC
31270502 PubMed citation Europe PMC
32327527 PubMed citation Europe PMC
33222246 PubMed citation Europe PMC
33661013 PubMed citation Europe PMC
35324190 PubMed citation Europe PMC
35483199 PubMed citation Europe PMC
37356504 PubMed citation Europe PMC
38064417 PubMed citation Europe PMC
38285887 PubMed citation Europe PMC
Last Modified
08 April 2024