CHEBI:229233 - ritlecitinib

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ChEBI Name ritlecitinib
ChEBI ID CHEBI:229233
Definition A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a [(3R,6S)-6-methyl-1-(prop-2-enoyl)piperidin-3-yl]amino group. It is a dual inhibitor of Janus kinase 3 and the TEC family of tyrosine kinases.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C15H19N5O
Net Charge 0
Average Mass 285.351
Monoisotopic Mass 285.15896
InChI InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
InChIKey CBRJPFGIXUFMTM-WDEREUQCSA-N
SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)NC1=C2C=CNC2=NC=N1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
Application(s): dermatologic drug
A drug used to treat or prevent skin disorders or for the routine care of skin.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
anti-inflammatory drug
A substance that reduces or suppresses inflammation.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ritlecitinib (CHEBI:229233) has role anti-inflammatory drug (CHEBI:35472)
ritlecitinib (CHEBI:229233) has role antirheumatic drug (CHEBI:35842)
ritlecitinib (CHEBI:229233) has role dermatologic drug (CHEBI:50177)
ritlecitinib (CHEBI:229233) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
ritlecitinib (CHEBI:229233) has role immunosuppressive agent (CHEBI:35705)
ritlecitinib (CHEBI:229233) is a N-acylpiperidine (CHEBI:48591)
ritlecitinib (CHEBI:229233) is a acrylamides (CHEBI:22216)
ritlecitinib (CHEBI:229233) is a pyrrolopyrimidine (CHEBI:38670)
ritlecitinib (CHEBI:229233) is a secondary amino compound (CHEBI:50995)
ritlecitinib (CHEBI:229233) is a tertiary carboxamide (CHEBI:140326)
ritlecitinib (CHEBI:229233) is conjugate base of ritlecitinib(1+) (CHEBI:229235)
Incoming ritlecitinib(1+) (CHEBI:229235) is conjugate acid of ritlecitinib (CHEBI:229233)
IUPAC Name
1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
INNs Sources
ritlecitinib WHO MedNet
ritlécitinib WHO MedNet
ritlecitinib WHO MedNet
ritlecitinibum WHO MedNet
Synonyms Sources
PF 06651600 ChEBI
PF-06651600 DrugBank
PF06651600 ChEBI
Manual Xrefs Databases
DB14924 DrugBank
Ritlecitinib Wikipedia
View more database links
Registry Number Type Source
1792180-81-4 CAS Registry Number DrugBank
Citations Waiting for Citations Types Sources
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Last Modified
17 April 2024