CHEBI:197440 - Recombinant Tumor Necrosis Factor-alpha (human)

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ChEBI Name Recombinant Tumor Necrosis Factor-alpha (human)
ChEBI ID CHEBI:197440
Definition TNF-alpha is released from macrophages, monocytes, neutrophils, T-cells (principally CD4+), NK-cells and many transformed cell lines. Soluble homotrimeric TNF-alpha released from cells by proteolysis of the integral membrane precursor form of TNF-alpha. TNF-alpha binding to some TNF-alpha receptors induces apoptosis and depending on cell type, receptor expression, and signal transduction status can induce other responses. TNF-a is involved in the inflammatory response.
Stars This entity has been manually annotated by a third party.
Submitter Jonathan Muyskens
ChEBI Ontology
Outgoing Recombinant Tumor Necrosis Factor-alpha (human) (CHEBI:197440) is a organic molecular entity (CHEBI:50860)
Synonyms Sources
Cachectin SUBMITTER
Differentiation inducing factor (DIF) SUBMITTER
Macrophage cytotoxic factor (MCF) SUBMITTER
Necrosin SUBMITTER
TNFSF2 SUBMITTER
Tumor necrosis factor-alpha SUBMITTER