3PO (CHEBI:144367)

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ChEBI Name	3PO

ChEBI ID	CHEBI:144367

Definition	A member of the class of pyridines that is pyridine substituted by a 3-oxo-3-(pyridin-4-yl)prop-1-en-1-yl group at position 3. An inhibitor of PFKFB3 kinase, an enzyme with a key role in glycolysis.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Sabrina Toro

Supplier Information

Download	Molfile XML SDF

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Formula

C13H10N2O

Net Charge

Average Mass

210.236

Monoisotopic Mass

210.07931

InChI

InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+

InChIKey

UOWGYMNWMDNSTL-ONEGZZNKSA-N

SMILES

N=1C=C(C=CC1)/C=C/C(C2=CC=NC=C2)=O

Roles Classification
Biological Role(s):	autophagy inducer Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of 6-phosphofructo-2-kinase (EC 2.7.1.105).

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology
Outgoing	3PO (CHEBI:144367) has role angiogenesis inhibitor (CHEBI:48422) 3PO (CHEBI:144367) has role antineoplastic agent (CHEBI:35610) 3PO (CHEBI:144367) has role apoptosis inducer (CHEBI:68495) 3PO (CHEBI:144367) has role autophagy inducer (CHEBI:138880) 3PO (CHEBI:144367) has role EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor (CHEBI:144387) 3PO (CHEBI:144367) is a enone (CHEBI:51689) 3PO (CHEBI:144367) is a pyridines (CHEBI:26421)

IUPAC Name

(2E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one

Synonyms	Sources
(2E)-3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	ChEBI
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	SUBMITTER
3PO	SUBMITTER

Registry Number	Type	Source
18550-98-6	CAS Registry Number	ChEBI

Last Modified

01 August 2019