CHEBI:144984 - NSC 23766

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ChEBI Name NSC 23766
ChEBI ID CHEBI:144984
Definition An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:91883
Supplier Information
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Formula C24H35N7
Net Charge 0
Average Mass 421.593
Monoisotopic Mass 421.29539
InChI InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30)
InChIKey DEFBCZWQLILOJF-UHFFFAOYSA-N
SMILES CC(CCCN(CC)CC)NC1=NC(=CC(NC2=CC=3C(=NC(=CC3N)C)C=C2)=N1)C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 3.6.5.2 (small monomeric GTPase) inhibitor
Any EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor that interferes with the action of small monomeric GTPase (EC 3.6.5.2).
antiviral agent
A substance that destroys or inhibits replication of viruses.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
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ChEBI Ontology
Outgoing NSC 23766 (CHEBI:144984) has role antiviral agent (CHEBI:22587)
NSC 23766 (CHEBI:144984) has role apoptosis inducer (CHEBI:68495)
NSC 23766 (CHEBI:144984) has role EC 3.6.5.2 (small monomeric GTPase) inhibitor (CHEBI:144981)
NSC 23766 (CHEBI:144984) has role muscarinic antagonist (CHEBI:48876)
NSC 23766 (CHEBI:144984) is a aminopyrimidine (CHEBI:38338)
NSC 23766 (CHEBI:144984) is a aminoquinoline (CHEBI:36709)
NSC 23766 (CHEBI:144984) is a primary amino compound (CHEBI:50994)
NSC 23766 (CHEBI:144984) is a secondary amino compound (CHEBI:50995)
NSC 23766 (CHEBI:144984) is a tertiary amino compound (CHEBI:50996)
Incoming NSC 23766 trihydrochloride (CHEBI:144949) has part NSC 23766 (CHEBI:144984)
IUPAC Name
N6-(2-{[5-(diethylamino)pentan-2-yl]amino}-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
Synonyms Sources
N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine LINCS
NSC-23766 ChEBI
NSC23766 ChEBI
Manual Xref Database
LSM-1818 LINCS
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Citations Waiting for Citations Types Sources
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Last Modified
04 February 2020