CHEBI:172325 - STM2457

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ChEBI Name STM2457
ChEBI ID CHEBI:172325
Definition A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid with the primary amino group of 1-[2-(aminomethyl)imidazo[1,2-a]pyridin-6-yl]-N-(cyclohexylmethyl)methanamine. It is a highly potent and selective first-in-class small molecule inhibitor of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity and exhibits anti-leukaemic activity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C25H28N6O2
Net Charge 0
Average Mass 444.539
Monoisotopic Mass 444.22737
InChI InChI=1S/C25H28N6O2/c32-24-12-21(29-23-8-4-5-11-31(23)24)25(33)27-15-20-17-30-16-19(9-10-22(30)28-20)14-26-13-18-6-2-1-3-7-18/h4-5,8-12,16-18,26H,1-3,6-7,13-15H2,(H,27,33)
InChIKey OBERVORNENYOLE-UHFFFAOYSA-N
SMILES O=C(NCC1=CN2C=C(CNCC3CCCCC3)C=CC2=N1)C1=CC(=O)N2C=CC=CC2=N1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor
An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of mRNA m6A methyltransferase (EC 2.1.1.348).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing STM2457 (CHEBI:172325) has role antineoplastic agent (CHEBI:35610)
STM2457 (CHEBI:172325) has role apoptosis inducer (CHEBI:68495)
STM2457 (CHEBI:172325) has role EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor (CHEBI:172326)
STM2457 (CHEBI:172325) is a imidazopyridine (CHEBI:46908)
STM2457 (CHEBI:172325) is a pyridopyrimidine (CHEBI:38932)
STM2457 (CHEBI:172325) is a secondary amino compound (CHEBI:50995)
STM2457 (CHEBI:172325) is a secondary carboxamide (CHEBI:140325)
IUPAC Name
N-[(6-{[(cyclohexylmethyl)amino]methyl}imidazo[1,2-a]pyridin-2-yl)methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide
Synonyms Sources
STM 2457 ChEBI
STM-2457 ChEBI
Manual Xref Database
WO2020201773 Patent
View more database links
Citation Waiting for Citations Type Source
33902106 PubMed citation Europe PMC
Last Modified
29 April 2021