CHEBI:67173 - cortistatin B

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ChEBI Name cortistatin B
ChEBI ID CHEBI:67173
Definition A member of the class of cortistatins that is cortistatin A in which the hydrogen at the 16β position has been replaced by a hydroxy group.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C30H36N2O4
Net Charge 0
Average Mass 488.61780
Monoisotopic Mass 488.26751
InChI InChI=1S/C30H36N2O4/c1-28-8-6-20-13-21-26(34)27(35)22(32(2)3)15-29(21)9-10-30(20,36-29)24(28)14-23(33)25(28)18-5-4-17-7-11-31-16-19(17)12-18/h4-7,11-13,16,22-27,33-35H,8-10,14-15H2,1-3H3/t22-,23-,24+,25-,26+,27+,28-,29+,30+/m0/s1
InChIKey UOILBRZCKBLNDS-KMWHWPCOSA-N
SMILES [H][C@@]12C[C@H](O)[C@H](c3ccc4ccncc4c3)[C@@]1(C)CC=C1C=C3[C@@H](O)[C@H](O)[C@H](C[C@]33CC[C@]21O3)N(C)C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Application(s): angiogenesis modulating agent
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
(via cortistatins )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing cortistatin B (CHEBI:67173) has functional parent cortistatin A (CHEBI:67171)
cortistatin B (CHEBI:67173) is a cortistatins (CHEBI:67169)
cortistatin B (CHEBI:67173) is a diol (CHEBI:23824)
cortistatin B (CHEBI:67173) is a secondary alcohol (CHEBI:35681)
Incoming cortistatin C (CHEBI:67174) has functional parent cortistatin B (CHEBI:67173)
IUPAC Name
(1R,2R,3S,5R)-3-(dimethylamino)-17β-(isoquinolin-7-yl)-5,8α-epoxy-9,19-cyclo-9,10-secoandrosta-9(11),10-diene-1,2,16β-triol
Synonyms Sources
(+)-cortistatin B ChEBI
(1R,2R,3S,5R,8α,16β,17β)-3-(dimethylamino)-17-(isoquinolin-7-yl)-5,8-epoxy-9,19-cyclo-9,10-secoandrosta-9(11),10-diene-1,2,16-triol IUPAC
Registry Number Type Source
10503473 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
16522087 PubMed citation Europe PMC
17765550 PubMed citation Europe PMC
Last Modified
21 August 2012