CHEBI:88334 - CD437

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ChEBI Name CD437
ChEBI ID CHEBI:88334
Definition A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)γ and induces cell cycle arrest and apoptosis in various cancer cells.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): retinoic acid receptor gamma agonist
Any retinoic acid receptor (RAR) agonist with specificity for RARgamma.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): retinoic acid receptor gamma agonist
Any retinoic acid receptor (RAR) agonist with specificity for RARgamma.
Related Structures
CD437 is a Functional Parent of
adapalene
Mass : 412.521
Formula : C28H28O3
31174
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