CHEBI:64159 - 2-methyl-6-(phenylethynyl)pyridine

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ChEBI Name 2-methyl-6-(phenylethynyl)pyridine
ChEBI ID CHEBI:64159
Definition A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Biological Role(s): metabotropic glutamate receptor antagonist
An antagonist at the metabotropic glutamate receptor.
Application(s): anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
Related Structures
2-methyl-6-(phenylethynyl)pyridine is a Structural Derivative of
acetylene
Mass : 26.03728
Formula : C2H2
27518
2-methyl-6-(phenylethynyl)pyridine is a Conjugate Base of
2-methyl-6-(phenylethynyl)pyridinium(1+)
Mass : 194.25180
Formula : C14H12N
64160
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